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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL3966784
Molecular formula	C17H21Cl2N3O2S
IUPAC name	1-(5-chloro-1,3-dimethylpyrazol-4-yl)sulfonyl-4-[(4-chlorophenyl)methyl]piperidine
Molecular weight	402.334
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.1
Synonyms	SCHEMBL15549113 1-((5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-4-(4 chlorobenzyl)piperidine US9475795, 68 BDBM250589 1-((5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl)-4-(4chlorobenzyl)piperidine BOTHEIGTHCWZNG-UHFFFAOYSA-N [ Show all ]
Inchi Key	BOTHEIGTHCWZNG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H21Cl2N3O2S/c1-12-16(17(19)21(2)20-12)25(23,24)22-9-7-14(8-10-22)11-13-3-5-15(18)6-4-13/h3-6,14H,7-11H2,1-2H3
PubChem CID	72550668
ChEMBL	CHEMBL3966784
IUPHAR	N/A
BindingDB	250589
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2020.0 nM	, None	BindingDB,ChEMBL

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