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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL3900223
Molecular formula	C18H25N3O3S
IUPAC name	4-(2,6-dimethylphenoxy)-1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperidine
Molecular weight	363.476
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.1
Synonyms	1-(3,5-Dimethyl-1H-pyrazole-4-sulfonyl)-4-(2,6-dimethylphenoxyl)piperidine SCHEMBL15549545 US9475795, 38 1-(3,5-Dimethyl-1H-pyrazole-4-sulfonyl)-4-(2,6-dimethylphenoxy)piperidine BDBM250559 FGVBKKDHMNXMNK-UHFFFAOYSA-N [ Show all ]
Inchi Key	FGVBKKDHMNXMNK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H25N3O3S/c1-12-6-5-7-13(2)17(12)24-16-8-10-21(11-9-16)25(22,23)18-14(3)19-20-15(18)4/h5-7,16H,8-11H2,1-4H3,(H,19,20)
PubChem CID	72550005
ChEMBL	CHEMBL3900223
IUPHAR	N/A
BindingDB	250559
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3200.0 nM	, None	BindingDB,ChEMBL

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