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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL3908365
Molecular formula	C18H21Cl2N3O3S
IUPAC name	(3,4-dichlorophenyl)-[1-(1,3,5-trimethylpyrazol-4-yl)sulfonylpiperidin-4-yl]methanone
Molecular weight	430.344
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.3
Synonyms	BDBM250571 HGVPENVIWXZAFS-UHFFFAOYSA-N (3,4-Dichlorophenyl)(1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)methanone SCHEMBL15548691 US9475795, 50
Inchi Key	HGVPENVIWXZAFS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H21Cl2N3O3S/c1-11-18(12(2)22(3)21-11)27(25,26)23-8-6-13(7-9-23)17(24)14-4-5-15(19)16(20)10-14/h4-5,10,13H,6-9H2,1-3H3
PubChem CID	72550224
ChEMBL	CHEMBL3908365
IUPHAR	N/A
BindingDB	250571
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2100.0 nM	, None	BindingDB,ChEMBL

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