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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL3912835
Molecular formula	C17H22ClN3O3S
IUPAC name	1-(5-chloro-1,3-dimethylpyrazol-4-yl)sulfonyl-4-(4-methylphenoxy)piperidine
Molecular weight	383.891
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.3
Synonyms	BDBM250532 HUKSKLPHAFYRMC-UHFFFAOYSA-N 1-[(5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-(4-methylphenoxyl)piperidine SCHEMBL15549314 1-[(5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-(4-methylphenoxy)piperidine US9475795, 11 [ Show all ]
Inchi Key	HUKSKLPHAFYRMC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H22ClN3O3S/c1-12-4-6-14(7-5-12)24-15-8-10-21(11-9-15)25(22,23)16-13(2)19-20(3)17(16)18/h4-7,15H,8-11H2,1-3H3
PubChem CID	72549098
ChEMBL	CHEMBL3912835
IUPHAR	N/A
BindingDB	250532
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	860.0 nM	, None	BindingDB,ChEMBL

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