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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL3905662
Molecular formula	C17H23ClN4O4S
IUPAC name	5-chloro-3-methoxy-2-[1-(1,3,5-trimethylpyrazol-4-yl)sulfonylpiperidin-4-yl]oxypyridine
Molecular weight	414.905
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	2.3
Synonyms	SCHEMBL15549434 5-chloro-3-methoxy-2-((1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-yl)oxy)pyridine US9475795, 84 BDBM250605 HXYYINKUXKDVIA-UHFFFAOYSA-N
Inchi Key	HXYYINKUXKDVIA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H23ClN4O4S/c1-11-16(12(2)21(3)20-11)27(23,24)22-7-5-14(6-8-22)26-17-15(25-4)9-13(18)10-19-17/h9-10,14H,5-8H2,1-4H3
PubChem CID	72551108
ChEMBL	CHEMBL3905662
IUPHAR	N/A
BindingDB	250605
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	720.0 nM	, None	BindingDB,ChEMBL

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