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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL3949632
Molecular formula	C18H22ClF2N3O2S
IUPAC name	4-[1-(4-chlorophenyl)-2,2-difluoroethyl]-1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperidine
Molecular weight	417.9
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.1
Synonyms	SCHEMBL15549273 4-(1-(4-Chlorophenyl)-2,2-difluoroethyl)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine US9475795, 111 BDBM250632 KSXBFKHWLTYGHZ-UHFFFAOYSA-N
Inchi Key	KSXBFKHWLTYGHZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H22ClF2N3O2S/c1-11-17(12(2)23-22-11)27(25,26)24-9-7-14(8-10-24)16(18(20)21)13-3-5-15(19)6-4-13/h3-6,14,16,18H,7-10H2,1-2H3,(H,22,23)
PubChem CID	72548146
ChEMBL	CHEMBL3949632
IUPHAR	N/A
BindingDB	250632
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	340.0 nM	, None	BindingDB,ChEMBL

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