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Name | P2Y purinoceptor 14 |
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Species | Homo sapiens (Human) |
Gene | P2RY14 |
Synonym | G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 [ Show all ] |
Disease | N/A |
Length | 338 |
Amino acid sequence | MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL |
UniProt | Q15391 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q15391 |
3D structure model | This predicted structure model is from GPCR-EXP Q15391. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4518 |
IUPHAR | 330 |
DrugBank | N/A |
Name | GTPL9471 |
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Molecular formula | C41H47BF2N6O19P2S |
IUPAC name | [(2R,3R,4S,5S,6S)-6-[5-[[2-[4-(2,2-difluoro-12-thiophen-2-yl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)phenoxy]acetyl]amino]pentylcarbamoyl]-3,4,5-trihydroxyoxan-2-yl] [[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate |
Molecular weight | 1070.66 |
Hydrogen bond acceptor | 23 |
Hydrogen bond donor | 10 |
XlogP | None |
Synonyms | MRS4183 compound 11 [PMID: 26303895] |
Inchi Key | DXQJLXWZLNCEJX-VBCGWZPHSA-N |
Inchi ID | InChI=1S/C41H47BF2N6O19P2S/c43-42(44)49-23(19-24-9-13-27(50(24)42)29-5-4-18-72-29)8-12-26(49)22-6-10-25(11-7-22)64-21-31(52)45-15-2-1-3-16-46-38(58)37-34(55)33(54)36(57)40(67-37)68-71(62,63)69-70(60,61)65-20-28-32(53)35(56)39(66-28)48-17-14-30(51)47-41(48)59/h4-14,17-19,28,32-37,39-40,53-57H,1-3,15-16,20-21H2,(H,45,52)(H,46,58)(H,60,61)(H,62,63)(H,47,51,59)/t28?,32?,33-,34-,35?,36+,37-,39?,40+/m0/s1 |
PubChem CID | 124221652 |
ChEMBL | N/A |
IUPHAR | 9471 |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 0.96 nM | PMID26303895 | IUPHAR |
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