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GPCR

NameGastric inhibitory polypeptide receptor
SpeciesHomo sapiens (Human)
GeneGIPR
SynonymGIP-R
GIP receptor
Glucose-dependent insulinotropic polypeptide receptor
Gippr
DiseaseType 2 diabetes
Length466
Amino acid sequenceMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProtP48546
Protein Data BankN/A
GPCR-HGmod modelP48546
3D structure modelThis predicted structure model is from GPCR-EXP P48546.
BioLiPN/A
Therapeutic Target DatabaseT41750
ChEMBLCHEMBL4383
IUPHAR248
DrugBankN/A

Ligand

Nameaminothiazole, 5
Molecular formulaC38H34ClN3O3S
IUPAC name3-[[4-[[N-[4-(4-chlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-4-(cyclohexen-1-yl)anilino]methyl]benzoyl]amino]propanoic acid
Molecular weight648.218
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP8.9
SynonymsCHEMBL443971
BDBM29108
SCHEMBL2649096
Inchi KeyFTBIQPJNXCTJIU-UHFFFAOYSA-N
Inchi IDInChI=1S/C38H34ClN3O3S/c39-32-19-15-29(16-20-32)35-36(30-9-5-2-6-10-30)46-38(41-35)42(33-21-17-28(18-22-33)27-7-3-1-4-8-27)25-26-11-13-31(14-12-26)37(45)40-24-23-34(43)44/h2,5-7,9-22H,1,3-4,8,23-25H2,(H,40,45)(H,43,44)
PubChem CID22496431
ChEMBLCHEMBL443971
IUPHARN/A
BindingDB29108
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501002.0 nMPMID19385613BindingDB,ChEMBL

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