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GPCR

Name	Gastric inhibitory polypeptide receptor
Species	Homo sapiens (Human)
Gene	GIPR
Synonym	GIP-R GIP receptor Glucose-dependent insulinotropic polypeptide receptor Gippr
Disease	Type 2 diabetes
Length	466
Amino acid sequence	MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProt	P48546
Protein Data Bank	N/A
GPCR-HGmod model	P48546
3D structure model	This predicted structure model is from GPCR-EXP P48546.
BioLiP	N/A
Therapeutic Target Database	T41750
ChEMBL	CHEMBL4383
IUPHAR	248
DrugBank	N/A

Ligand

Name	CHEMBL198387
Molecular formula	C29H34F3N7O3
IUPAC name	4-[[9-tert-butyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[5.5]undecan-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamide
Molecular weight	585.632
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	5.9
Synonyms	BDBM50171819 SCHEMBL2665867 Benzamide,4-[[9-(1,1-dimethylethyl)-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[5.5]undec-1-yl]methyl]-N-2H-tetrazol-5-yl- ZINC6718454 CHEMBL502203 BDBM50244078 SCHEMBL5946516 4-({9-t-butyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[5.5]undec-1-yl}methyl)-N-(2h-tetrazol-5-yl)benzamide 706812-04-6 KB-74945 Benzamide, 4-[[9-(1,1-dimethylethyl)-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[5.5]undec-1-yl]methyl]-N-2H-tetrazol-5-yl- trans-4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-N-(1H-tetrazol-5-yl)-benzamide 4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[5.5]undec-1-ylmethyl]-N-(1H-tetrazol-5-yl)-benzamide [ Show all ]
Inchi Key	FVDONABKZHMTCY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H34F3N7O3/c1-27(2,3)21-12-14-28(15-13-21)16-17-38(22-8-10-23(11-9-22)42-29(30,31)32)26(41)39(28)18-19-4-6-20(7-5-19)24(40)33-25-34-36-37-35-25/h4-11,21H,12-18H2,1-3H3,(H2,33,34,35,36,37,40)
PubChem CID	10054055
ChEMBL	CHEMBL198387
IUPHAR	N/A
BindingDB	50171819
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	430.0 nM	PMID16102966	BindingDB
IC50	430.0 nM	PMID16102966	ChEMBL

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