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GPCR

Name	Gastric inhibitory polypeptide receptor
Species	Homo sapiens (Human)
Gene	GIPR
Synonym	GIP-R GIP receptor Glucose-dependent insulinotropic polypeptide receptor Gippr
Disease	Type 2 diabetes
Length	466
Amino acid sequence	MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProt	P48546
Protein Data Bank	N/A
GPCR-HGmod model	P48546
3D structure model	This predicted structure model is from GPCR-EXP P48546.
BioLiP	N/A
Therapeutic Target Database	T41750
ChEMBL	CHEMBL4383
IUPHAR	248
DrugBank	N/A

Ligand

Name	CHEMBL504245
Molecular formula	C32H31F3N4O5
IUPAC name	(2R)-3-[[4-[[N-[[4-cyano-3-(trifluoromethyl)phenyl]carbamoyl]-4-cyclohexylanilino]methyl]benzoyl]amino]-2-hydroxypropanoic acid
Molecular weight	608.618
Hydrogen bond acceptor	9
Hydrogen bond donor	4
XlogP	5.5
Synonyms	(R)-3-{4-[3-(4-Cyano-3-trifluoromethylphenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid BDBM50245061 SCHEMBL2651818 (R)-3-{4-[3-(4-Cyano-3-trifluoromethylphenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoyl-amino}-2-hydroxypropionic acid ANMUHQCUTMTNRH-MUUNZHRXSA-N
Inchi Key	ANMUHQCUTMTNRH-MUUNZHRXSA-N
Inchi ID	InChI=1S/C32H31F3N4O5/c33-32(34,35)27-16-25(13-10-24(27)17-36)38-31(44)39(26-14-11-22(12-15-26)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(41)37-18-28(40)30(42)43/h6-16,21,28,40H,1-5,18-19H2,(H,37,41)(H,38,44)(H,42,43)/t28-/m1/s1
PubChem CID	10282370
ChEMBL	CHEMBL504245
IUPHAR	N/A
BindingDB	50245061
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	198.0 nM	PMID18707090	BindingDB,ChEMBL

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