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Name | Neuromedin-K receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Tacr3 |
Synonym | Tac3r SP-N receptor Nmkr NKR NK3 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 452 |
Amino acid sequence | MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS |
UniProt | P16177 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3154 |
IUPHAR | 362 |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
2496 | Substance P | C63H98N18O13S | 1347.65 | 17 / 15 | -2.3 | No |
5217 | CHEMBL296014 | C32H47N3O5 | 553.744 | 5 / 4 | 5.6 | No |
8428 | CHEMBL3144347 | C42H46N6O7 | 746.865 | 7 / 3 | 4.2 | No |
8430 | CHEMBL45085 | C42H46N6O7 | 746.865 | 7 / 3 | 4.2 | No |
16017 | CHEMBL152239 | C27H29FN2 | 400.541 | 3 / 1 | 5.5 | No |
18975 | CHEMBL65468 | C39H35F6N8O5- | 809.75 | 15 / 3 | 5.2 | No |
24271 | Talnetant | C25H22N2O2 | 382.463 | 3 / 2 | 5.7 | No |
29735 | CHEMBL441454 | C45H66N12O7S | 919.16 | 10 / 10 | 1.1 | No |
30739 | CHEMBL265115 | C49H76N12O9S | 1009.28 | 11 / 10 | 0.9 | No |
31772 | CHEMBL266884 | C41H52N8O7S | 800.976 | 8 / 6 | 2.8 | No |
442910 | CHEMBL3349688 | C41H52N8O7S | 800.976 | 8 / 6 | 2.8 | No |
443042 | CHEMBL3422010 | C21H19N5OS2 | 421.537 | 6 / 0 | 3.0 | Yes |
34848 | CHEMBL262048 | C39H57N7O6S | 751.988 | 8 / 6 | 3.0 | No |
34852 | CHEMBL407511 | C39H57N7O6S | 751.988 | 8 / 6 | 3.0 | No |
36139 | PD157672 | C32H47N5O5 | 581.758 | 5 / 5 | 4.5 | No |
36214 | L-732,138 | C22H18F6N2O3 | 472.387 | 9 / 2 | 4.7 | Yes |
43106 | CHEMBL157858 | C37H43N5O6 | 653.78 | 6 / 4 | 3.4 | No |
44157 | CHEMBL410808 | C69H102N18O13S | 1423.75 | 17 / 15 | -0.9 | No |
49800 | CHEMBL3144343 | C41H44N6O6 | 716.839 | 6 / 3 | 3.8 | No |
49806 | CHEMBL296267 | C41H44N6O6 | 716.839 | 6 / 3 | 3.8 | No |
51869 | LANEPITANT | C33H45N5O3 | 559.755 | 5 / 2 | 4.2 | No |
51870 | CHEMBL351236 | C33H45N5O3 | 559.755 | 5 / 2 | 4.2 | No |
52026 | GR 94800 | C49H61N9O8 | 904.082 | 8 / 7 | 4.4 | No |
55677 | CHEMBL2370069 | C50H71N13O11 | 1030.2 | 12 / 9 | 3.5 | No |
57199 | CHEMBL264341 | C63H96N18O13S | 1345.63 | 17 / 15 | -2.2 | No |
57203 | CHEMBL265573 | C63H96N18O13S | 1345.63 | 17 / 15 | -2.2 | No |
58282 | CHEMBL1760338 | C21H21ClN4O2 | 396.875 | 4 / 1 | 3.9 | Yes |
444069 | CHEMBL3422018 | C20H18N6OS2 | 422.525 | 7 / 0 | 2.8 | Yes |
65977 | CHEMBL422779 | C42H62N10O7S | 851.081 | 9 / 8 | 1.9 | No |
68057 | CHEMBL264353 | C69H100N18O13S | 1421.73 | 17 / 15 | -1.2 | No |
68568 | CP-99994 | C19H24N2O | 296.414 | 3 / 2 | 2.9 | Yes |
72878 | Osanetant | C35H41Cl2N3O2 | 606.632 | 3 / 0 | 7.0 | No |
81428 | CP 96345 | C28H32N2O | 412.577 | 3 / 1 | 5.4 | No |
81441 | CHEMBL346154 | C28H32N2O | 412.577 | 3 / 1 | 5.4 | No |
81447 | CHEMBL419500 | C28H32N2O | 412.577 | 3 / 1 | 5.4 | No |
98762 | CHEMBL2372521 | C71H102N18O13S | 1447.77 | 17 / 15 | -1.0 | No |
103239 | CHEMBL2372516 | C72H104N18O13S | 1461.8 | 17 / 14 | -0.4 | No |
524543 | CHEMBL3734811 | C39H53N7O11S | 827.951 | 12 / 8 | 2.0 | No |
524548 | CHEMBL3736361 | C39H53N7O11S | 827.951 | 12 / 8 | 2.0 | No |
445974 | CHEMBL3422015 | C23H23N5O2S | 433.53 | 6 / 0 | 3.1 | Yes |
112524 | NEUROKININ A | C50H80N14O14S | 1133.33 | 18 / 16 | -4.8 | No |
117946 | CHEMBL297376 | C44H48N6O8 | 788.902 | 8 / 4 | 3.2 | No |
117952 | CHEMBL3144351 | C44H48N6O8 | 788.902 | 8 / 4 | 3.2 | No |
118617 | Senktide | C40H55N7O11S | 841.978 | 12 / 8 | 1.1 | No |
120381 | CHEMBL2370702 | C38H50N8O7S | 762.927 | 8 / 8 | 2.2 | No |
446435 | 125989-12-0 | C38H50N8O7S | 762.927 | 8 / 8 | 2.2 | No |
477860 | CHEMBL3608740 | C16H16N6OS | 340.405 | 6 / 0 | 1.5 | Yes |
125283 | CHEMBL131872 | C42H68N10O11S | 921.125 | 14 / 11 | -3.1 | No |
129888 | CHEMBL267924 | C52H71N13O7 | 990.224 | 9 / 12 | 3.7 | No |
143277 | CHEMBL45340 | C29H40F2N4O4 | 546.66 | 6 / 4 | 5.2 | No |
144037 | CHEMBL262049 | C36H53N7O6S | 711.923 | 8 / 7 | 2.0 | No |
153936 | CHEMBL219162 | C25H21N3O4 | 427.46 | 5 / 1 | 4.8 | Yes |
155588 | CHEMBL411230 | C64H100N18O13S | 1361.68 | 17 / 15 | -2.0 | No |
155775 | CHEMBL2372517 | C72H106N18O13S | 1463.81 | 17 / 14 | -0.2 | No |
159643 | CHEMBL152011 | C22H28N2O | 336.479 | 3 / 1 | 3.9 | Yes |
169541 | CHEMBL346633 | C28H32N2 | 396.578 | 2 / 1 | 5.8 | No |
169890 | CHEMBL265155 | C60H100N18O13S2 | 1345.69 | 18 / 15 | -2.9 | No |
172024 | CHEMBL276294 | C60H100N18O15S2 | 1377.69 | 19 / 15 | -4.3 | No |
177952 | CHEMBL405422 | C60H100N18O13S2 | 1345.69 | 18 / 15 | -3.0 | No |
189898 | CHEMBL153042 | C28H31ClN2 | 431.02 | 2 / 1 | 6.5 | No |
190800 | CHEMBL406142 | C82H102N16O14S2 | 1599.94 | 16 / 12 | 5.3 | No |
449180 | CHEMBL3349687 | C82H102N16O14S2 | 1599.94 | 16 / 12 | 5.3 | No |
191043 | CHEMBL437060 | C48H58N6O6 | 815.028 | 6 / 3 | 6.8 | No |
191047 | CHEMBL3144339 | C48H58N6O6 | 815.028 | 6 / 3 | 6.8 | No |
196880 | CHEMBL356912 | C27H29ClN2 | 416.993 | 2 / 1 | 6.0 | No |
203261 | CHEMBL152055 | C20H24N2 | 292.426 | 2 / 1 | 3.4 | Yes |
205421 | CHEMBL321228 | C46H69N11O8S | 936.187 | 10 / 9 | 1.4 | No |
449887 | CHEMBL3361404 | C41H56N6O10S | 824.991 | 11 / 7 | 2.1 | No |
209096 | CHEMBL406442 | C69H102N18O13S | 1423.75 | 17 / 15 | -0.9 | No |
449973 | CHEMBL3422017 | C20H18N6O2S | 406.464 | 7 / 0 | 2.2 | Yes |
216652 | CHEMBL10079 | C25H22N2O | 366.464 | 2 / 1 | 5.6 | No |
218652 | CHEMBL3144340 | C42H46N6O6 | 730.866 | 6 / 3 | 3.8 | No |
218656 | CHEMBL46849 | C42H46N6O6 | 730.866 | 6 / 3 | 3.8 | No |
219731 | CHEMBL264395 | C45H67N11O8S | 922.16 | 10 / 9 | 1.0 | No |
220294 | CHEMBL406812 | C65H100N18O13S | 1373.69 | 17 / 15 | -2.0 | No |
220298 | CHEMBL216813 | C65H100N18O13S | 1373.69 | 17 / 15 | -2.0 | No |
223769 | Neurokinin B | C55H79N13O14S2 | 1210.43 | 18 / 14 | -1.6 | No |
229547 | CHEMBL134481 | C44H66N10O11S | 943.131 | 14 / 12 | -2.8 | No |
230352 | CHEMBL2370055 | C49H68N10O10 | 957.143 | 10 / 8 | 2.9 | No |
230893 | CHEMBL1368916 | C50H72N12O9 | 985.201 | 10 / 9 | 2.9 | No |
232465 | CHEMBL2115376 | C65H100N18O13S | 1373.69 | 17 / 15 | -2.1 | No |
232466 | CHEMBL2114443 | C65H100N18O13S | 1373.69 | 17 / 15 | -2.1 | No |
239543 | CHEMBL278294 | C27H30ClN5 | 460.022 | 4 / 0 | N/A | N/A |
528506 | CHEMBL3736089 | C40H55N7O11S | 841.978 | 12 / 8 | 2.3 | No |
242670 | CHEMBL335054 | C40H66N10O11S | 895.087 | 14 / 12 | -3.5 | No |
451703 | CHEMBL3349511 | C40H52N8O9S | 820.963 | 10 / 8 | 1.4 | No |
254035 | CHEMBL269731 | C40H52N8O9S | 820.963 | 10 / 8 | 1.4 | No |
254176 | CHEMBL3144353 | C41H46N6O5 | 702.856 | 5 / 3 | 3.9 | No |
254186 | CHEMBL296441 | C41H46N6O5 | 702.856 | 5 / 3 | 3.9 | No |
264672 | CHEMBL156186 | C36H41N5O6 | 639.753 | 6 / 4 | 3.0 | No |
495786 | Fezolinetant | C16H15FN6OS | 358.395 | 7 / 0 | 1.6 | Yes |
267304 | CHEMBL3144209 | C47H57N7O6 | 816.016 | 7 / 4 | 4.4 | No |
267312 | BDBM50045036 | C47H58N7O6+ | 817.024 | 6 / 4 | 4.4 | No |
272268 | CHEMBL405209 | C69H100N18O13S | 1421.73 | 17 / 15 | -1.2 | No |
287752 | CHEMBL106184 | C42H65N11O7S | 868.112 | 10 / 9 | 0.8 | No |
289452 | CHEMBL449347 | C28H31NO2 | 413.561 | 3 / 0 | 5.6 | No |
295900 | CHEMBL346626 | C29H33ClN2 | 445.047 | 2 / 1 | 6.8 | No |
499882 | CHEMBL3608688 | C16H12F4N6OS | 412.367 | 10 / 0 | 2.1 | Yes |
307628 | CHEMBL267712 | C48H70N10O11S | 995.207 | 14 / 10 | -2.3 | No |
309608 | Spantide I | C75H108N20O13 | 1497.82 | 16 / 17 | 0.6 | No |
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