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Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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Ligand

Name	rofecoxib
Molecular formula	C17H14O4S
IUPAC name	3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one
Molecular weight	314.355
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	2.3
Synonyms	KBio2_002345 4-(4-(Methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one KBioGR_002345 A810324 Merck brand of rofecoxib AC1L1JL6 MK-966 BIDD:GT0399 MolPort-000-883-878 CCG-40253 NCGC00095118-05 CPD000466331 PubChem15028 DSSTox_RID_77084 rofecoxibum HMS2051G16 011R907 HSDB 7262 3-(4-methanesulfonyl-phenyl)-2-phenyl-2-buten-4-olide Tox21_111430 Vioxx; 4-[4-(Methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one SCHEMBL3050 Spectrum5_001598 3-(Phenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone KBio2_005695 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one KS-00000XKS AB00052090_09 MK 0966 AN-25306 MLS000759440 BSPBio_002705 NC00132 Ceoxx NSC-720256 D05VLS refecoxib EX-A708 HMS2232G21 186912-82-3 J10420 SR-01000762904-3 VA11689 s3043 SpecPlus_000669 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone KBio3_002825 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one LS-70511 AB07701 MK 996 BCP03619 MLS001424113 Cahill May Roberts brand of rofecoxib NCGC00095118-03 CHEMBL122 NSC758705 DSSTox_CID_3567 Rofecoxib (Vioxx) GTPL2893 HMS3651F16 2(5H)-Furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl- KBio1_001709 STK635144 Vioxx (trademark) SBI-0206774.P001 Spectrum3_001153 KBio2_003127 4-(4-METHANESULFONYL-PHENYL)-3-PHENYL-5H-FURAN-2-ONE KBioSS_000559 AB00052090-06 Merck Frosst brandof rofecoxib AJ-08299 MK0966 BRD-K21733600-001-02-6 MolPort-006-817-786 CCRIS 8967 NCGC00095118-08 CS-0997 Q-201676 DTXSID2023567 RT-016235 HMS2089H20 0QTW8Z7MCR HY-17372 3-(4-methanesulfonylphenyl)-2-phenyl-2-buten-4-olide TRM-201 ZB000656 SMR000466331 Spectrum_000119 3-Phenyl-4-(4-(methylsulfonyl)phenyl))-2(5H)-furanone KBio2_007481 4-(p-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone KS-1107 AB00052090_10 MK 0996 ANW-71936 MLS001165770 C07590 NCGC00095118-01 Ceoxx (TN) NSC-758705 DB00533 FT-0081390 HMS3371P11 2(5H)-Furanone, 4-(4-(methylsulfonyl)phenyl)-3-phenyl- Jsp003237 SR-01000762904-5 Vioxx SAM001246617 SPECTRUM1504235 KBio2_000559 4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone KBioGR_001242 544684-93-7 MCULE-4806636118 AC-28318 MK-0966 BDBM22369 MLS006010091 CAS-162011-90-7 NCGC00095118-04 cMAP_000024 Pharmakon1600-01504235 DSSTox_GSID_23567 Rofecoxib [USAN:INN:BAN] HMS1922H11 HMS3713B07 SW219668-1 Vioxx Dolor SC-17320 Spectrum4_000631 KBio2_004913 4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one KBioSS_002348 AB00052090-08 Merck Sharp & Dhome brand of rofecoxib AKOS000280931 MK966 BRD-K21733600-001-06-7 MSD brand of rofecoxib Ceeoxx (TN) NCI60_041175 D00568 R0206 EBD34785 HMS2093E04 162011-90-7 I01-1042 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one SR-01000762904 UNII-0QTW8Z7MCR ZINC7455 RZJQGNCSTQAWON-UHFFFAOYSA-N SPBio_000492 3-Phenyl-4-(4-(Methylsulfonyl)Phenyl)-2-(5H)-Furanone KBio3_002205 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone L000912 AB0012045 MK 966 AOB6956 MLS001195623 C17H14O4S NCGC00095118-02 CHEBI:8887 NSC720256 DivK1c_006765 Rofecoxib (JAN/USAN/INN) FT-0631192 HMS3393G16 2(5H)-Furanone, 4-[4-(methyl-sulfonyl)phenyl]-3-phenyl- K-5064 ST2410970 Vioxx (TN) SB19518 Spectrum2_000446 [ Show all ]
Inchi Key	RZJQGNCSTQAWON-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
PubChem CID	5090
ChEMBL	N/A
IUPHAR	N/A
BindingDB	22369
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
308844	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
308835	5-hydroxytryptamine receptor 1B	P28222	HTR1B	Homo sapiens (Human)	390
308847	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
308851	5-hydroxytryptamine receptor 1E	P28566	HTR1E	Homo sapiens (Human)	365
308831	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
308840	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
308836	5-hydroxytryptamine receptor 6	P50406	HTR6	Homo sapiens (Human)	440
308845	5-hydroxytryptamine receptor 7	P34969	HTR7	Homo sapiens (Human)	479
308843	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
308838	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
308853	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
308842	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
308837	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
308830	Cannabinoid receptor 2	P34972	CNR2	Homo sapiens (Human)	360
308854	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
308841	D(1B) dopamine receptor	P21918	DRD5	Homo sapiens (Human)	477
308834	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
308852	Histamine H2 receptor	P25021	HRH2	Homo sapiens (Human)	359
308839	Histamine H3 receptor	Q9JI35	HRH3	Cavia porcellus (Guinea pig)	445
308846	Kappa-type opioid receptor	P41145	OPRK1	Homo sapiens (Human)	380