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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	1,3,7-trimethyl-5-((2-oxo-2-(piperidin-1-yl)ethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
Molecular formula	C16H21N5O3S
IUPAC name	1,3,7-trimethyl-5-(2-oxo-2-piperidin-1-ylethyl)sulfanylpyrimido[4,5-d]pyrimidine-2,4-dione
Molecular weight	363.436
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	1.0
Synonyms	CCG-30066 SR-01000132146 1,3,7-trimethyl-5-(2-oxo-2-piperidin-1-ylethyl)sulfanylpyrimido[4,5-d]pyrimidine-2,4-dione EU-0093472 AC1NDYHV MolPort-003-040-878 SR-01000132146-1 F0654-0013 AKOS024592576 SCHEMBL1279533 CHEMBL3962122 ZINC4138740 852167-87-4 MCULE-6247397479 [ Show all ]
Inchi Key	VIFDCVBUAQDKDB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H21N5O3S/c1-10-17-13-12(15(23)20(3)16(24)19(13)2)14(18-10)25-9-11(22)21-7-5-4-6-8-21/h4-9H2,1-3H3
PubChem CID	4608957
ChEMBL	CHEMBL3962122
IUPHAR	N/A
BindingDB	211237
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	292.0 nM	N/A	BindingDB
IC50	292.0 nM	None	ChEMBL

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