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| Name | Sphingosine 1-phosphate receptor 1 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | S1PR1 |
| Synonym | Sphingosine 1-phosphate receptor Edg-1 S1P1 receptor S1P1 S1P receptor Edg-1 S1P receptor 1 [ Show all ] |
| Disease | Immune disorder Macular degeneration Hepatocellular carcinoma; Multiple scierosis Multiple scierosis Primary progressive multiple sclerosis [ Show all ] |
| Length | 382 |
| Amino acid sequence | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS |
| UniProt | P21453 |
| Protein Data Bank | 3v2w |
| GPCR-HGmod model | P21453 |
| 3D structure model | This structure is from PDB ID 3v2w. |
| BioLiP | BL0214678 |
| Therapeutic Target Database | T13852 |
| ChEMBL | CHEMBL4333 |
| IUPHAR | 275 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 32 |  MLS000077136 | C12H11N3O6 | 293.235 | 8 / 1 | -0.1 | Yes |
| 147 |  CHEMBL325198 | C19H34NO3P | 355.459 | 4 / 3 | 2.0 | Yes |
| 303 |  SCHEMBL2458105 | C27H35NO4S | 469.64 | 5 / 2 | 4.9 | Yes |
| 557318 |  BDBM65291 | C25H33FNO5P | 477.513 | 7 / 3 | 1.4 | Yes |
| 462 |  SCHEMBL2948159 | C22H25ClO3S | 404.949 | 4 / 1 | 5.1 | No |
| 441689 |  CHEMBL3403625 | C22H17F3N2O5 | 446.382 | 9 / 1 | 3.3 | Yes |
| 542 |  MLS000761483 | C20H19ClN2O | 338.835 | 3 / 1 | 4.5 | Yes |
| 635 |  SCHEMBL460059 | C25H28N4O4 | 448.523 | 8 / 1 | 0.3 | Yes |
| 557325 |  BDBM65164 | C22H36NO4PS | 441.567 | 6 / 3 | 1.1 | Yes |
| 557327 |  BDBM65165 | C22H36NO4PS | 441.567 | 6 / 3 | 1.1 | Yes |
| 441699 |  CHEMBL3402538 | C13H17ClN4O2S | 328.815 | 5 / 1 | 1.7 | Yes |
| 840 |  SMR000178156 | C18H11N3O4 | 333.303 | 5 / 0 | 3.2 | Yes |
| 535930 |  CHEMBL3937763 | C25H24N4O4 | 444.491 | 8 / 1 | 1.2 | Yes |
| 535931 |  SCHEMBL1880639 | C25H24N4O4 | 444.491 | 8 / 1 | 1.2 | Yes |
| 535932 |  SCHEMBL1880072 | C25H24N4O4 | 444.491 | 8 / 1 | 1.2 | Yes |
| 521475 |  CHEMBL3753198 | C20H22N6O4 | 410.434 | 9 / 1 | 2.2 | Yes |
| 1373 |  SMR000023524 | C17H26N2O2 | 290.407 | 3 / 0 | 4.2 | Yes |
| 1395 |  MLS000057790 | C18H13N3O3 | 319.32 | 6 / 1 | 3.7 | Yes |
| 1486 |  CHEMBL2011712 | C19H20N4OS | 352.456 | 5 / 0 | 3.9 | Yes |
| 557345 |  SCHEMBL17056275 | C18H21ClIN | 413.727 | 1 / 0 | 6.3 | No |
| 535964 |  CHEMBL3970705 | C28H31N5O6S | 565.645 | 10 / 2 | 3.2 | No |
| 1953 |  CHEMBL2018573 | C28H25F2N5O3 | 517.537 | 7 / 1 | 4.9 | No |
| 2015 |  MLS000053810 | C21H22N2O5 | 382.416 | 5 / 1 | 2.7 | Yes |
| 2169 |  SR-02000000242 | C19H15Cl2NO2 | 360.234 | 2 / 1 | 5.8 | No |
| 2246 |  CHEMBL444799 | C21H17F2N3O3S | 429.442 | 9 / 1 | 4.4 | Yes |
| 2341 |  CHEMBL3126597 | C26H35N5O5 | 497.596 | 9 / 3 | 3.2 | Yes |
| 557367 |  SCHEMBL17056279 | C16H16Cl3NO | 344.66 | 2 / 1 | 4.9 | Yes |
| 2962 |  CHEMBL1950564 | C26H24FN3O2S | 461.555 | 7 / 2 | 2.6 | Yes |
| 2971 |  CHEMBL1938927 | C26H24FN3O2S | 461.555 | 7 / 1 | 2.6 | Yes |
| 459253 |  SCHEMBL3033160 | C26H36N6O | 448.615 | 6 / 2 | 3.6 | Yes |
| 535994 |  CHEMBL3901430 | C27H31N5O4S | 521.636 | 9 / 1 | 3.8 | No |
| 557380 |  BDBM65105 | C24H32NO5P | 445.496 | 6 / 3 | 0.6 | Yes |
| 557381 |  BDBM65106 | C24H32NO5P | 445.496 | 6 / 3 | 0.6 | Yes |
| 3500 |  CHEMBL377828 | C26H29N3O3 | 431.536 | 6 / 2 | 3.0 | Yes |
| 521554 |  CHEMBL3800120 | C26H32N4O6 | 496.564 | 9 / 3 | 3.2 | Yes |
| 557399 |  SCHEMBL17056394 | C18H19ClN2 | 298.814 | 2 / 0 | 5.0 | Yes |
| 463374 |  CHEMBL3605520 | C18H20ClN3O3S | 393.886 | 5 / 2 | 2.4 | Yes |
| 4060 |  4035-38-5 | C19H15ClN2O | 322.792 | 3 / 0 | 4.8 | Yes |
| 536030 |  CHEMBL3910626 | C28H33N5O2 | 471.605 | 7 / 1 | 4.6 | Yes |
| 4176 |  SMR000094562 | C23H26N4O2S | 422.547 | 6 / 0 | 3.6 | Yes |
| 521569 |  CHEMBL3797365 | C26H34N4O6 | 498.58 | 9 / 3 | 3.2 | Yes |
| 4346 |  CHEMBL537632 | C20H31N3O2 | 345.487 | 4 / 4 | 3.2 | Yes |
| 4369 |  MLS000056039 | C18H21NO3S | 331.43 | 4 / 0 | 3.6 | Yes |
| 4387 |  CHEMBL117973 | C18H40NO3P | 349.496 | 4 / 3 | 3.3 | Yes |
| 536050 |  CHEMBL3949905 | C26H28N4O2 | 428.536 | 6 / 0 | 5.1 | No |
| 4623 |  SMR000019512 | C15H8ClNO3S2 | 349.803 | 5 / 0 | 3.9 | Yes |
| 4632 |  diethyl (4-bromobenzylidene)malonate | C14H15BrO4 | 327.174 | 4 / 0 | 4.0 | Yes |
| 4889 |  SMR000033264 | C22H18N4O2 | 370.412 | 5 / 1 | 3.8 | Yes |
| 5085 |  CYM50199 | C14H12BrCl2NO2 | 377.059 | 3 / 0 | 5.2 | No |
| 536065 |  CHEMBL3971646 | C25H26N4O6S | 510.565 | 10 / 1 | 3.1 | No |
| 5179 |  2-Amino-N-ethyl-5-nitrobenzenesulfonanilide | C14H15N3O4S | 321.351 | 6 / 1 | 2.7 | Yes |
| 441906 |  CHEMBL3359840 | C24H24N4O5 | 448.479 | 9 / 1 | 0.8 | Yes |
| 463509 |  CHEMBL3605529 | C16H17ClN4O2S | 364.848 | 5 / 1 | 2.5 | Yes |
| 536070 |  CHEMBL3948795 | C27H29N5O4 | 487.56 | 7 / 2 | 3.4 | Yes |
| 536071 |  CHEMBL3977376 | C27H29N5O4 | 487.56 | 7 / 2 | 3.4 | Yes |
| 536072 |  CHEMBL3939061 | C27H29N5O4 | 487.56 | 7 / 2 | 3.4 | Yes |
| 536073 |  CHEMBL3958210 | C27H29N5O4 | 487.56 | 7 / 2 | 3.4 | Yes |
| 5482 |  CHEMBL224571 | C23H19ClF3NO3S | 481.914 | 8 / 1 | 3.1 | Yes |
| 536078 |  CHEMBL3971447 | C25H27N5O2 | 429.524 | 7 / 1 | 3.5 | Yes |
| 536079 |  CHEMBL3974002 | C25H27N5O2 | 429.524 | 7 / 1 | 3.5 | Yes |
| 5663 |  CHEMBL3121985 | C26H33N3O5S | 499.626 | 8 / 3 | 4.6 | Yes |
| 441921 |  CHEMBL3360364 | C21H20N4O2 | 360.417 | 6 / 1 | 3.4 | Yes |
| 5968 |  CHEMBL1938943 | C23H16F3N3O2 | 423.395 | 7 / 1 | 4.6 | Yes |
| 5993 |  SCHEMBL2237381 | C21H24ClF3N2O2 | 428.88 | 7 / 3 | 2.9 | Yes |
| 6039 |  CHEMBL2011719 | C19H20N4O2S | 368.455 | 6 / 0 | 3.5 | Yes |
| 6042 |  MLS000080860 | C16H16O5S2 | 352.419 | 5 / 1 | 1.4 | Yes |
| 536092 |  CHEMBL3954502 | C25H29N3O4 | 435.524 | 6 / 2 | 3.4 | Yes |
| 6256 |  MLS000094175 | C17H18N2O2S3 | 378.523 | 6 / 1 | 4.4 | Yes |
| 6324 |  CHEMBL211407 | C21H21ClN2O4 | 400.859 | 6 / 1 | 4.4 | Yes |
| 6371 |  MLS000035729 | C20H22FNO3 | 343.398 | 5 / 0 | 3.0 | Yes |
| 6376 |  SMR000032959 | C20H22ClN5O3 | 415.878 | 7 / 1 | 4.1 | Yes |
| 536100 |  SCHEMBL2197188 | C22H20N4O2 | 372.428 | 6 / 1 | 3.2 | Yes |
| 557466 |  3-(3-(4-Octylphenyl)-2-oxoimidazolidin-1-yl)propanoic acid | C20H30N2O3 | 346.471 | 3 / 1 | 4.6 | Yes |
| 6597 |  CHEMBL3126596 | C27H34N4O5 | 494.592 | 8 / 3 | 4.0 | Yes |
| 521639 |  CHEMBL3797486 | C27H36N4O6 | 512.607 | 9 / 3 | 4.1 | No |
| 521650 |  CHEMBL3770278 | C18H19ClN4O3S | 406.885 | 7 / 1 | 4.0 | Yes |
| 7076 |  CHEMBL3126622 | C27H34N4O5 | 494.592 | 8 / 3 | 3.6 | Yes |
| 521657 |  CHEMBL3771073 | C22H24N6O3S | 452.533 | 9 / 1 | 0.3 | Yes |
| 441996 |  CHEMBL3344423 | C22H22Cl2FN5O4 | 510.347 | 9 / 2 | 3.0 | No |
| 7361 |  Cuspin-1 | C13H10BrNO | 276.133 | 2 / 0 | 3.3 | Yes |
| 7539 |  SMR000204386 | C12H13NO5 | 251.238 | 5 / 0 | 2.4 | Yes |
| 7681 |  CHEMBL196534 | C25H27N3O3 | 417.509 | 6 / 1 | 2.9 | Yes |
| 7818 |  MLS000056228 | C12H11N3S2 | 261.361 | 5 / 0 | 3.0 | Yes |
| 8061 |  CHEMBL1950562 | C25H22FN3O2S | 447.528 | 7 / 2 | 5.5 | No |
| 442040 |  CHEMBL3341925 | C23H29N2O6P | 460.467 | 8 / 4 | -0.2 | Yes |
| 8310 |  SCHEMBL2945721 | C21H25NO3S | 371.495 | 4 / 2 | 3.7 | Yes |
| 8341 |  CHEMBL2032437 | C29H27F3N2O3 | 508.541 | 8 / 1 | 4.3 | No |
| 8590 |  CHEMBL1672569 | C25H20ClFN2O2S | 466.955 | 6 / 1 | 3.6 | Yes |
| 557520 |  BDBM65262 | C22H31N2O6PS | 482.532 | 9 / 3 | -1.3 | Yes |
| 8955 |  CHEMBL117007 | C19H34NO4P | 371.458 | 5 / 4 | 0.6 | Yes |
| 9257 |  CHEMBL2336069 | C29H35F3N2O3 | 516.605 | 8 / 2 | 4.6 | No |
| 9559 |  SCHEMBL2235117 | C22H27ClN2O2 | 386.92 | 4 / 2 | 2.5 | Yes |
| 9704 |  CHEMBL1916567 | C24H24ClN3O5 | 469.922 | 7 / 1 | 4.2 | Yes |
| 9726 |  CHEMBL2178810 | C27H29ClN2O5S | 529.048 | 6 / 2 | 5.6 | No |
| 9786 |  CHEMBL1935579 | C26H32ClNO3 | 441.996 | 4 / 2 | N/A | N/A |
| 9847 |  CHEMBL396846 | C35H43NaO4S2 | 614.835 | 5 / 0 | N/A | No |
| 9975 |  CHEMBL2011747 | C26H25F3N4O3S | 530.566 | 9 / 1 | 5.4 | No |
| 10093 |  SCHEMBL461450 | C27H31ClN2O4 | 483.005 | 6 / 2 | 6.7 | No |
| 10102 |  CHEMBL226612 | C20H34FN2O5P | 432.473 | 7 / 4 | 2.2 | Yes |
| 557574 |  BDBM65133 | C26H37N2O5P | 488.565 | 7 / 3 | 0.1 | Yes |
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