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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL2205915
Molecular formula	C18H15N5O2S
IUPAC name	13-(cyclopropylamino)-5-(4-methoxyphenyl)-8-thia-3,5,10,12-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one
Molecular weight	365.411
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.3
Synonyms	D0SB7U 13-(cyclopropylamino)-5-(4-methoxyphenyl)-8-thia-3,5,10,12-tetraazatricyclo[7.4.0.0^{2,7}]trideca-1(13),2(7),3,9,11-pentaen-6-one GTPL6365 BDBM50401676 compound 10i [PMID: 23084894] SCHEMBL8242394 [ Show all ]
Inchi Key	DBUMITZHDMTTNX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H15N5O2S/c1-25-12-6-4-11(5-7-12)23-9-21-14-13-16(22-10-2-3-10)19-8-20-17(13)26-15(14)18(23)24/h4-10H,2-3H2,1H3,(H,19,20,22)
PubChem CID	57559562
ChEMBL	CHEMBL2205915
IUPHAR	6365
BindingDB	50401676
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
56018	Metabotropic glutamate receptor 1	Q13255	GRM1	Homo sapiens (Human)	1194
56019	Metabotropic glutamate receptor 1	P23385	Grm1	Rattus norvegicus (Rat)	1199
56017	Metabotropic glutamate receptor 5	P41594	GRM5	Homo sapiens (Human)	1212

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