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| Name | Metabotropic glutamate receptor 1 |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Grm1 |
| Synonym | mGluR1 SCAR13 mGlu1 receptor metabotropic glutamate receptor 1 wobl [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 1199 |
| Amino acid sequence | MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQQPPPQQPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNSLRSLYPPPPPPQHLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYEREGNTEEDELEEEEDLPTASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL |
| UniProt | P23385 |
| Protein Data Bank | 1iss, 1isr, 1ewk |
| GPCR-HGmod model | N/A |
| 3D structure model | This structure is from PDB ID 1iss. |
| BioLiP | BL0023849, BL0023850,BL0023851, BL0011887,BL0011889, BL0011888,BL0011890 |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL4477 |
| IUPHAR | 289 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 112 |  CHEMBL278949 | C13H15NO5 | 265.265 | 6 / 3 | -1.6 | Yes |
| 2930 |  CHEMBL224615 | C17H14N4OS | 322.386 | 5 / 0 | 3.2 | Yes |
| 555488 |  AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
| 4246 |  CHEMBL1783868 | C20H18N4OS | 362.451 | 5 / 1 | 4.7 | Yes |
| 4689 |  CHEMBL243020 | C19H21N3O2 | 323.396 | 2 / 3 | 2.7 | Yes |
| 6311 |  CHEMBL1951882 | C19H14BrN3OS | 412.305 | 4 / 1 | 4.9 | Yes |
| 6662 |  CHEMBL401270 | C23H23N3O | 357.457 | 4 / 0 | 3.9 | Yes |
| 6712 |  CHEMBL334842 | C6H9N3O3S | 203.216 | 6 / 3 | -3.4 | Yes |
| 6715 |  CHEMBL131922 | C6H9N3O3S | 203.216 | 6 / 3 | -3.4 | Yes |
| 7202 |  CHEMBL238262 | C17H11N5OS | 333.369 | 5 / 1 | 3.1 | Yes |
| 7789 |  CHEMBL224322 | C21H24N4OS | 380.51 | 5 / 0 | 4.3 | Yes |
| 7996 |  CHEMBL386408 | C17H21N5O2S | 359.448 | 6 / 0 | 2.3 | Yes |
| 10104 |  CHEMBL469386 | C15H20N4O2 | 288.351 | 6 / 2 | 2.2 | Yes |
| 10331 |  CHEMBL252736 | C16H19N3O | 269.348 | 4 / 1 | 3.4 | Yes |
| 10816 |  CHEMBL1783862 | C19H15FN4O2S | 382.413 | 7 / 1 | 3.8 | Yes |
| 11413 |  CHEMBL246449 | C23H26N4O2 | 390.487 | 5 / 3 | 3.4 | Yes |
| 521772 |  CHEMBL2312685 | C8H16N2O4 | 204.226 | 6 / 4 | -6.8 | Yes |
| 12610 |  CHEMBL234062 | C18H20N2O | 280.371 | 3 / 2 | 3.0 | Yes |
| 12908 |  VU 0361737 | C13H11ClN2O2 | 262.693 | 3 / 1 | 2.6 | Yes |
| 13318 |  QUISQUALIC ACID | C5H7N3O5 | 189.127 | 6 / 3 | -3.9 | Yes |
| 555530 |  2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid | C5H7N3O5 | 189.127 | 6 / 3 | -3.9 | Yes |
| 14017 |  CHEMBL561189 | C19H14ClNO | 307.777 | 2 / 0 | 5.3 | No |
| 14198 |  CHEMBL235975 | C18H14N4O2S | 350.396 | 6 / 1 | 3.2 | Yes |
| 15044 |  CHEMBL197629 | C7H10N2O5 | 202.166 | 7 / 3 | -3.4 | Yes |
| 15158 |  CHEMBL67769 | C17H21N3O4 | 331.372 | 6 / 1 | 3.4 | Yes |
| 15162 |  CHEMBL513032 | C18H19N5O | 321.384 | 6 / 3 | 2.5 | Yes |
| 15345 |  CHEMBL388087 | C18H16N4OS | 336.413 | 5 / 0 | 3.1 | Yes |
| 15576 |  CHEMBL1951670 | C18H14N2O3S | 338.381 | 5 / 0 | 3.6 | Yes |
| 16023 |  CHEMBL367027 | C12H12N2O5 | 264.237 | 6 / 4 | -2.3 | Yes |
| 19479 |  CHEMBL1784054 | C18H14ClN5OS | 383.854 | 6 / 1 | 4.6 | Yes |
| 20425 |  CHEMBL401331 | C22H27N3O | 349.478 | 4 / 1 | 5.1 | No |
| 20860 |  CHEMBL426018 | C20H20N4OS | 364.467 | 5 / 0 | 4.5 | Yes |
| 22399 |  CHEMBL479804 | C8H14N2O5 | 218.209 | 6 / 4 | -3.3 | Yes |
| 22609 |  CHEMBL215240 | C18H15FN4OS | 354.403 | 6 / 0 | 3.3 | Yes |
| 23444 |  CHEMBL180011 | C23H27NO | 333.475 | 2 / 0 | 5.7 | No |
| 23673 |  CHEMBL224375 | C18H13F3N4OS | 390.384 | 8 / 0 | 4.1 | Yes |
| 23923 |  CHEMBL225124 | C17H13FN4OS | 340.376 | 6 / 0 | 3.3 | Yes |
| 522265 |  CHEMBL3786667 | C8H11NO6 | 217.177 | 7 / 4 | -4.0 | Yes |
| 522267 |  CHEMBL3787264 | C8H11NO6 | 217.177 | 7 / 4 | -4.0 | Yes |
| 522280 |  CHEMBL3786026 | C8H11NO6 | 217.177 | 7 / 4 | -4.0 | Yes |
| 522285 |  CHEMBL3786938 | C8H11NO6 | 217.177 | 7 / 4 | -4.0 | Yes |
| 24442 |  CHEMBL497918 | C15H21N5 | 271.368 | 5 / 1 | 3.1 | Yes |
| 26928 |  CHEMBL538307 | C19H23NO | 281.399 | 2 / 0 | 3.3 | Yes |
| 27652 |  CHEMBL472489 | C18H19N5 | 305.385 | 5 / 1 | 3.3 | Yes |
| 28448 |  CID 69467219 | C15H13NO | 223.275 | 2 / 0 | 2.7 | Yes |
| 28450 |  CHEMBL561590 | C15H13NO | 223.275 | 2 / 0 | 2.7 | Yes |
| 28471 |  CHEMBL233851 | C18H16N2O2 | 292.338 | 2 / 2 | 3.2 | Yes |
| 31624 |  CHEMBL178592 | C19H22ClNO2 | 331.84 | 3 / 0 | 4.7 | Yes |
| 31633 |  CHEMBL1951688 | C18H15N3OS | 321.398 | 4 / 1 | 4.0 | Yes |
| 32610 |  CHEMBL1951666 | C19H16FN3O2S | 369.414 | 6 / 0 | 3.9 | Yes |
| 33370 |  CHEMBL494961 | C17H10F2N2O3 | 328.275 | 6 / 1 | 2.9 | Yes |
| 33517 |  CHEMBL2179631 | C28H27NO5 | 457.526 | 5 / 1 | 4.8 | Yes |
| 33800 |  CHEMBL246456 | C21H28N4O2 | 368.481 | 5 / 2 | 2.7 | Yes |
| 36579 |  CHEMBL496897 | C18H19N5 | 305.385 | 5 / 1 | 3.3 | Yes |
| 37460 |  CHEMBL242344 | C12H19N3O3 | 253.302 | 5 / 3 | -0.3 | Yes |
| 39961 |  CHEMBL1783875 | C19H14N4OS | 346.408 | 5 / 1 | 3.5 | Yes |
| 40858 |  CHEMBL472490 | C17H17N5 | 291.358 | 5 / 2 | 3.2 | Yes |
| 41318 |  CHEMBL494967 | C18H9F5N2O3 | 396.273 | 9 / 1 | 3.9 | Yes |
| 41933 |  CHEMBL236177 | C19H16N4O3S | 380.422 | 7 / 1 | 3.2 | Yes |
| 555636 |  (R)-3-Carboxy-4-hydroxyphenylglycine | C9H9NO5 | 211.173 | 6 / 4 | -1.2 | Yes |
| 555638 |  (S)-3C4HPG | C9H9NO5 | 211.173 | 6 / 4 | -1.2 | Yes |
| 42658 |  N-cyclohexylquinazolin-4-amine | C14H17N3 | 227.311 | 3 / 1 | 4.2 | Yes |
| 553457 |  FTIDC | C18H23FN6O | 358.421 | 5 / 0 | 1.6 | Yes |
| 43878 |  CHEMBL1784075 | C18H10N6OS2 | 390.439 | 8 / 1 | 3.3 | Yes |
| 43930 |  CHEMBL143966 | C23H21N5O3S3 | 511.633 | 9 / 1 | 3.0 | No |
| 44375 |  CHEMBL1209401 | C26H33ClN2O3 | 457.011 | 4 / 1 | 8.2 | No |
| 44930 |  VU0080241 | C19H23N5 | 321.428 | 4 / 0 | 4.3 | Yes |
| 45033 |  CHEMBL471242 | C17H15N3 | 261.328 | 3 / 1 | 4.5 | Yes |
| 45299 |  CHEMBL203461 | C25H34N4O4 | 454.571 | 5 / 0 | 3.0 | Yes |
| 45900 |  CHEMBL1951883 | C18H16N4O2S | 352.412 | 6 / 0 | 3.5 | Yes |
| 45980 |  CHEMBL1951889 | C18H16N4OS | 336.413 | 5 / 1 | 4.1 | Yes |
| 522880 |  CHEMBL3785899 | C15H19N5 | 269.352 | 4 / 1 | 3.2 | Yes |
| 522882 |  CHEMBL3785407 | C15H19N5 | 269.352 | 4 / 1 | 3.2 | Yes |
| 553467 |  [11C]MMTP | C18H16N4O2S | 351.412 | 6 / 0 | 3.2 | Yes |
| 46907 |  CHEMBL428909 | C18H16N4O2S | 352.412 | 6 / 0 | 3.2 | Yes |
| 47641 |  CHEMBL254429 | C19H27N3O2 | 329.444 | 4 / 1 | 3.4 | Yes |
| 49907 |  CHEMBL1784050 | C19H13FN4O2S | 380.397 | 7 / 1 | 3.2 | Yes |
| 51032 |  CHEMBL557769 | C19H24O3 | 300.398 | 3 / 0 | 5.2 | No |
| 51122 |  CHEMBL561391 | C20H16ClNO2 | 337.803 | 3 / 0 | 5.3 | No |
| 51217 |  CHEMBL252531 | C18H17N3O | 291.354 | 4 / 0 | 2.7 | Yes |
| 469259 |  CHEMBL3628115 | C19H12ClN3O4 | 381.772 | 5 / 1 | 2.6 | Yes |
| 553493 |  BAY 36-7620 | C19H18O2 | 278.351 | 2 / 0 | 3.9 | Yes |
| 51967 |  CHEMBL469383 | C16H23N5O | 301.394 | 6 / 2 | 2.8 | Yes |
| 54822 |  CHEMBL492570 | C18H10F4N2O3 | 378.283 | 8 / 1 | 3.8 | Yes |
| 553507 |  Ro67-7476 | C17H18FNO2S | 319.394 | 4 / 0 | 3.6 | Yes |
| 55888 |  CHEMBL252941 | C21H21N3O | 331.419 | 4 / 1 | 4.5 | Yes |
| 56019 |  CHEMBL2205915 | C18H15N5O2S | 365.411 | 7 / 1 | 3.3 | Yes |
| 469947 |  CHEMBL3628112 | C20H12Cl2N2O4 | 415.226 | 4 / 1 | 4.3 | Yes |
| 57041 |  CHEMBL177866 | C22H21NO2 | 331.415 | 3 / 0 | 4.7 | Yes |
| 57077 |  CHEMBL1744061 | C14H17N3O3S | 307.368 | 5 / 2 | 1.7 | Yes |
| 57293 |  L-AP4 | C4H10NO5P | 183.1 | 6 / 4 | -5.5 | Yes |
| 57893 |  CHEMBL247485 | C17H20N4O | 296.374 | 4 / 1 | 2.3 | Yes |
| 58688 |  CHEMBL389585 | C8H13N3O3 | 199.21 | 5 / 3 | -2.1 | Yes |
| 60612 |  CHEMBL67143 | C19H30N2O4 | 350.459 | 5 / 1 | 3.9 | Yes |
| 61894 |  CHEMBL204802 | C18H26N2O3 | 318.417 | 3 / 0 | 3.2 | Yes |
| 61961 |  CHEMBL224672 | C18H22N4OS | 342.461 | 5 / 0 | 3.9 | Yes |
| 62365 |  CHEMBL1784067 | C17H10ClN5OS | 367.811 | 6 / 1 | 3.5 | Yes |
| 62850 |  CHEMBL234138 | C11H14NO5P | 271.209 | 6 / 4 | -3.3 | Yes |
| 62852 |  CHEMBL392419 | C11H14NO5P | 271.209 | 6 / 4 | -3.3 | Yes |
| 62860 |  CHEMBL396319 | C11H14NO5P | 271.209 | 6 / 4 | -3.3 | Yes |
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