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GPCR

NameMotilin receptor
SpeciesHomo sapiens (Human)
GeneMLNR
SynonymGPR38
G protein-coupled receptor 38
G-protein coupled receptor 38
MTLR1
MTLR
[ Show all ]
DiseaseGastrointestinal disorders; Gastroesophageal reflux disease
Irritable bowel syndrome
Gastrointestinal disease
Gastroesophageal reflux disease
Gastric motility disorder
[ Show all ]
Length412
Amino acid sequenceMGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProtO43193
Protein Data BankN/A
GPCR-HGmod modelO43193
3D structure modelThis predicted structure model is from GPCR-EXP O43193.
BioLiPN/A
Therapeutic Target DatabaseT62306
ChEMBLCHEMBL2203
IUPHAR297
DrugBankBE0003521

Known ligands

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Total entries: 326
Page:  / 4 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
9172D structureCHEMBL489094C25H33FN4O424.5645 / 23.3Yes
12282D structureCHEMBL232154C29H40ClN7O4586.1346 / 62.4No
34302D structureCHEMBL437156C30H42N4O4522.695 / 54.5No
39692D structureCHEMBL210899C40H45N5O6691.8297 / 16.3No
40192D structureCHEMBL215292C26H38N4O6502.6127 / 50.1No
81402D structureCHEMBL44542C22H26N6O6470.4867 / 3-0.2Yes
81412D structureCHEMBL296962C22H26N6O6470.4867 / 3-0.2Yes
5532942D structureMA2029C31H46ClFN4O4593.1816 / 5N/ANo
108602D structureCHEMBL1079186C25H32N4O2S452.6175 / 24.7Yes
122092D structureCHEMBL214543C28H36N4O6524.6187 / 62.7No
134742D structureCHEMBL214815C30H42N4O4522.695 / 54.5No
165862D structureCHEMBL1078344C23H22ClNO2S411.9443 / 14.8Yes
169702D structureSCHEMBL2768193C26H27N5O2441.5356 / 13.1Yes
176112D structureSCHEMBL1704096C26H33N5O431.5845 / 22.9Yes
176122D structureSCHEMBL1704626C26H33N5O431.5845 / 22.9Yes
210412D structureCHEMBL378317C35H38Cl3FN4O5720.067 / 07.7No
216842D structureGM611C40H69NO12755.98713 / 24.1No
5481342D structuremitemcinalC40H69NO12755.98713 / 24.1No
247752D structureCHEMBL463881C30H36FN5O501.656 / 24.7No
259522D structureCHEMBL480219C28H35FN6O490.6276 / 23.8Yes
274622D structureCHEMBL232359C29H39ClN6O5587.1186 / 63.2No
277602D structureCHEMBL1078461C19H24N2O3S360.4725 / 12.6Yes
280942D structureCHEMBL1078863C27H37N3O3S483.6715 / 14.7Yes
281702D structureCHEMBL384501C31H44N4O5552.7166 / 44.5No
289442D structureSCHEMBL2767377C25H26F2N4O436.5076 / 13.3Yes
341262D structureCHEMBL489480C26H33N5O431.5845 / 22.9Yes
341272D structureSCHEMBL1704116C26H33N5O431.5845 / 22.9Yes
403672D structureCHEMBL481001C30H36FN5O501.656 / 24.4No
433862D structureCHEMBL475808C27H33N3O415.5814 / 24.0Yes
439282D structureSCHEMBL2766955C26H27N5O2441.5356 / 13.1Yes
442032D structureCipargaminC19H14Cl2FN3O390.2393 / 33.9Yes
464652D structureSCHEMBL2765432C27H31FN4O446.575 / 14.1Yes
485852D structureCHEMBL386036C28H36N4O6524.6187 / 62.8No
485862D structureCHEMBL215440C30H42N4O4522.695 / 44.5No
502502D structureSCHEMBL2765776C26H27N5O425.5365 / 13.2Yes
515752D structureCHEMBL262052C39H69NO12743.97613 / 33.3No
525812D structureSCHEMBL2004331C24H27FN4O2S454.5647 / 23.1Yes
529632D structureCHEMBL383881C30H40N4O5536.6736 / 54.1No
529642D structureCHEMBL387446C30H40N4O5536.6736 / 54.1No
529652D structureCHEMBL214702C30H40N4O5536.6736 / 54.1No
529662D structureCHEMBL214935C30H40N4O5536.6736 / 54.1No
534192D structureCHEMBL473921C30H36FN5O501.656 / 24.7No
548172D structureCHEMBL1079311C21H23ClN4O2S430.9515 / 23.6Yes
568282D structureSCHEMBL2765921C25H26F2N4O2452.5067 / 13.5Yes
576772D structureCHEMBL296748C39H43N7O7721.8158 / 43.5No
577362D structureSCHEMBL2767107C27H35N5O445.6115 / 12.6Yes
587482D structureCHEMBL266018C20H26N2O2S358.54 / 24.2Yes
605852D structureCHEMBL1078343C21H21NO2S351.4643 / 13.8Yes
611942D structureCHEMBL1078540C20H24N4O2352.4385 / 21.6Yes
615082D structureCHEMBL481192C28H34FN5OS507.6727 / 24.5No
647312D structureSCHEMBL1704702C26H33F3N4O474.5727 / 24.0Yes
647322D structureSCHEMBL1704164C26H33F3N4O474.5727 / 24.0Yes
655182D structureCHEMBL379519C34H37Cl3N4O4672.0445 / 25.7No
669922D structureCHEMBL1081860C21H21N5O2S407.4926 / 22.3Yes
671412D structureCHEMBL1078639C20H24N4O2352.4385 / 21.6Yes
677562D structureCHEMBL489297C27H37FN4O452.6185 / 24.3Yes
698332D structureCHEMBL274876C29H38F3N5O4577.6499 / 53.8No
714372D structureCHEMBL385087C34H44N4O4572.755 / 45.8No
5536322D structureN-ethyl,N-methyl EM-AC38H69NO13747.96414 / 53.1No
742162D structureSCHEMBL2765637C25H28FN5O2449.537 / 13.1Yes
762602D structureCHEMBL465094C30H35F2N5O519.6417 / 24.8No
818032D structureCHEMBL1078269C23H21N3O2S403.55 / 12.8Yes
5239532D structureBDBM9488C19H19F3N6O2420.3969 / 11.3Yes
834772D structureCHEMBL396413C30H40F3N7O4619.699 / 62.6No
836942D structureCHEMBL210923C38H44N4O5636.7936 / 15.9No
855032D structureyil-781C24H28FN3O2409.5055 / 04.1Yes
865252D structureCHEMBL480210C32H36FN3O2513.6575 / 15.0No
891662D structureCHEMBL1078807C27H32N2O2S448.6254 / 16.2No
894182D structureSCHEMBL2765832C25H26ClFN4O2468.9576 / 14.1Yes
909892D structureCHEMBL1078104C20H21ClN4O2S416.9245 / 23.2Yes
918892D structureCHEMBL384204C30H48N4O4528.7385 / 45.7No
5537232D structure[Leu13]motilinC121H190N34O352681.0540 / 37-14.1No
965012D structureCHEMBL1078208C23H28N4O3S440.5626 / 23.4Yes
971452D structureCHEMBL391045C28H38ClN5O4544.0936 / 53.5No
984082D structureCHEMBL234810C30H41ClN6O4585.1466 / 63.2No
1009102D structureCHEMBL501315C36H48N4O2568.8064 / 26.5No
1041512D structureCHEMBL1078207C26H26N4O2S458.585 / 24.2Yes
1101872D structureCHEMBL518261C29H40FN5O493.6716 / 24.5Yes
1118022D structureCHEMBL1078463C21H27N3O2S385.5265 / 12.8Yes
1129802D structureSCHEMBL1704649C25H32F2N4O442.5556 / 23.4Yes
1129812D structureSCHEMBL1704133C25H32F2N4O442.5556 / 23.4Yes
1130532D structureCHEMBL45905C29H32N6O6560.6117 / 31.8No
1130542D structureCHEMBL33827C29H32N6O6560.6117 / 31.8No
1177782D structureSCHEMBL2768052C26H29FN4O432.5435 / 13.6Yes
1203442D structureSCHEMBL1704149C25H32ClFN4O459.0065 / 23.9Yes
1205722D structureCHEMBL384698C31H42N4O4534.7015 / 54.9No
1215202D structureSCHEMBL1704176C27H37FN4O452.6185 / 24.3Yes
1247752D structureCHEMBL489479C28H39FN4O466.6455 / 24.6Yes
1265482D structureCHEMBL385673C32H43N5O4561.7275 / 54.7No
1267862D structureCHEMBL474934C26H35FN4O438.5915 / 23.7Yes
1294402D structureSCHEMBL2767434C25H28FN5O433.5316 / 13.0Yes
1298552D structureCHEMBL1077578C17H19NO2S301.4043 / 12.5Yes
1311752D structureSCHEMBL2767740C24H26FN5O419.5046 / 12.6Yes
1315932D structureCHEMBL1079187C25H32N4O2S452.6175 / 24.7Yes
1319942D structureCHEMBL212044C35H41Cl3N4O4688.0875 / 16.7No
1335342D structureSCHEMBL2000727C24H24F4N4O2S508.53610 / 23.6No
1368342D structureCHEMBL382612C35H38Cl4FN3O3709.5055 / 08.5No
1384052D structureCHEMBL386626C30H41N3O6539.6737 / 44.8No
1407272D structureCHEMBL232342C29H41N5O5539.6777 / 62.3No
1416612D structureCHEMBL215963C31H44N4O4536.7175 / 54.8No

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