●I-TASSER ●D-I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●D-QUARK ●DRfold ●DRfold2 ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●ATGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred ●TCRfinder

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●TM-search ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●DeepMSA2 ●rMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●HPmod ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Contact number for disease-associated and bengin mutations:

Download: [PNG] [SVG] [EPS].

Contact number Pathogenic mutations Benign mutations Mean 3.88 2.69 Median 4.00 2.00 T-test p-value 1.44e-299 *

Predicted stability change upon mutation (ΔΔG=ΔG_mutant-ΔG_wt; a postitive ΔΔG indicates a destabilizing mutation):

Download: [PNG] [SVG] [EPS].	EvoEF predicted ΔΔG ΔΔG Pathogenic mutations Benign mutations Mean 0.74 0.06 Median 0.50 -0.02 T-test p-value 1.60e-214 *
Download: [PNG] [SVG] [EPS].	FoldX predicted ΔΔG ΔΔG Pathogenic mutations Benign mutations Mean 1.72 0.51 Median 1.19 0.25 T-test p-value 3.82e-234 *

Probability of different types of amino acid changes:

Download: [PNG] [SVG] [EPS]. (A-B) Heatmaps for probability of different amino acid type combinations among pathogenic (A) and benign (B) mutations, where a brighter color means higher probability. (C) Heatmaps for the probability of different amino acid type combinations among pathogenic mutations minus that of benign mutations. Red and blue indicate higher probability for pathogenic and benign mutations, respectively. (D) Head-to-head comparison of probability for different amino acid types between pathogenic (x-axis) and benign (y-axis) mutations. The top 7 mutations with the largest differences are highlighted in red and blue for amino acid types common for pathogenic and benign mutations, respectively. For example, "LP" means a mutation from L to P.

Statistics for 251 different types of amino acid changes for pathogenic versus benign mutations. Amino acid type changes that appear in neither pathogenic nor benign mutations are excluded. Mutation (A) Probability in pathogenic mutation (B) Probability in benign mutation (C) Difference in probability Rate ratio (probability for pathgenic mutations divided by that of benign mutation) P-value of rate ratio test L→P 3.788e-02 1.181e-02 2.607e-02 3.208e+00 2.220e-16 G→R 3.851e-02 1.490e-02 2.361e-02 2.584e+00 2.220e-16 R→W 3.209e-02 1.629e-02 1.580e-02 1.970e+00 2.220e-16 R→C 3.543e-02 1.974e-02 1.569e-02 1.795e+00 2.220e-16 C→Y 1.758e-02 4.561e-03 1.302e-02 3.855e+00 2.220e-16 Y→C 1.897e-02 7.196e-03 1.178e-02 2.636e+00 2.220e-16 G→D 1.993e-02 8.235e-03 1.170e-02 2.420e+00 2.220e-16 C→R 1.663e-02 5.245e-03 1.138e-02 3.170e+00 2.220e-16 G→V 1.570e-02 5.245e-03 1.045e-02 2.993e+00 2.220e-16 R→P 1.312e-02 4.029e-03 9.093e-03 3.257e+00 2.220e-16 G→E 1.487e-02 6.689e-03 8.184e-03 2.223e+00 2.220e-16 L→R 1.091e-02 3.345e-03 7.563e-03 3.261e+00 2.220e-16 C→F 6.809e-03 1.216e-03 5.593e-03 5.598e+00 2.220e-16 E→K 2.568e-02 2.030e-02 5.385e-03 1.265e+00 3.465e-06 W→R 8.726e-03 3.953e-03 4.773e-03 2.207e+00 1.776e-15 G→C 6.379e-03 1.900e-03 4.479e-03 3.357e+00 2.220e-16 R→L 9.122e-03 4.840e-03 4.283e-03 1.885e+00 1.345e-11 D→Y 6.941e-03 2.838e-03 4.103e-03 2.446e+00 5.329e-15 W→C 5.388e-03 1.318e-03 4.070e-03 4.089e+00 2.220e-16 F→S 7.800e-03 3.953e-03 3.847e-03 1.973e+00 3.392e-11 C→G 4.627e-03 1.140e-03 3.487e-03 4.058e+00 2.220e-16 A→P 9.850e-03 6.411e-03 3.439e-03 1.536e+00 5.970e-07 C→W 4.396e-03 1.090e-03 3.306e-03 4.035e+00 2.220e-16 I→N 4.925e-03 1.774e-03 3.151e-03 2.777e+00 3.357e-13 C→S 6.379e-03 3.243e-03 3.136e-03 1.967e+00 2.529e-09 D→V 5.784e-03 2.661e-03 3.124e-03 2.174e+00 2.011e-10 A→D 6.677e-03 3.674e-03 3.002e-03 1.817e+00 4.147e-08 M→R 3.636e-03 8.362e-04 2.800e-03 4.348e+00 6.661e-16 D→G 9.651e-03 6.943e-03 2.708e-03 1.390e+00 1.074e-04 V→D 3.437e-03 1.115e-03 2.323e-03 3.083e+00 7.177e-11 G→S 1.798e-02 1.568e-02 2.296e-03 1.146e+00 2.192e-02 Y→D 3.173e-03 8.869e-04 2.286e-03 3.578e+00 7.959e-12 R→G 1.157e-02 9.451e-03 2.117e-03 1.224e+00 7.480e-03 V→G 5.586e-03 3.471e-03 2.114e-03 1.609e+00 4.191e-05 V→F 4.363e-03 2.331e-03 2.032e-03 1.872e+00 4.260e-06 V→E 3.603e-03 1.571e-03 2.032e-03 2.293e+00 1.365e-07 M→K 2.843e-03 8.108e-04 2.032e-03 3.506e+00 1.658e-10 I→S 3.008e-03 1.014e-03 1.994e-03 2.968e+00 3.020e-09 P→R 7.734e-03 5.828e-03 1.906e-03 1.327e+00 2.708e-03 W→S 2.446e-03 5.828e-04 1.863e-03 4.197e+00 8.965e-11 F→C 3.272e-03 1.419e-03 1.853e-03 2.306e+00 4.605e-07 Q→P 4.793e-03 2.965e-03 1.828e-03 1.617e+00 1.339e-04 H→P 3.669e-03 1.850e-03 1.819e-03 1.983e+00 5.737e-06 S→F 8.660e-03 6.867e-03 1.793e-03 1.261e+00 8.518e-03 W→G 2.413e-03 6.335e-04 1.779e-03 3.809e+00 8.250e-10 N→I 3.107e-03 1.343e-03 1.764e-03 2.313e+00 8.465e-07 D→H 5.751e-03 4.029e-03 1.722e-03 1.427e+00 1.418e-03 T→R 3.537e-03 1.951e-03 1.586e-03 1.813e+00 8.046e-05 L→Q 3.239e-03 1.672e-03 1.567e-03 1.937e+00 3.676e-05 F→V 2.909e-03 1.470e-03 1.439e-03 1.979e+00 6.051e-05 G→W 2.347e-03 9.629e-04 1.384e-03 2.437e+00 7.890e-06 N→K 7.172e-03 5.803e-03 1.370e-03 1.236e+00 2.874e-02 Y→N 2.148e-03 7.855e-04 1.363e-03 2.735e+00 2.668e-06 I→F 3.371e-03 2.052e-03 1.319e-03 1.643e+00 1.049e-03 A→E 3.801e-03 2.711e-03 1.090e-03 1.402e+00 1.431e-02 Y→S 2.545e-03 1.470e-03 1.075e-03 1.732e+00 1.968e-03 R→S 6.544e-03 5.499e-03 1.046e-03 1.190e+00 8.528e-02 R→H 2.819e-02 2.724e-02 9.544e-04 1.035e+00 4.663e-01 L→H 2.148e-03 1.292e-03 8.561e-04 1.662e+00 8.296e-03 W→L 1.454e-03 6.588e-04 7.955e-04 2.207e+00 1.626e-03 I→K 8.924e-04 3.041e-04 5.883e-04 2.935e+00 2.001e-03 N→Y 1.785e-03 1.216e-03 5.686e-04 1.467e+00 6.598e-02 S→W 1.190e-03 6.335e-04 5.564e-04 1.878e+00 2.026e-02 S→P 9.222e-03 8.691e-03 5.304e-04 1.061e+00 4.869e-01 F→I 1.719e-03 1.216e-03 5.025e-04 1.413e+00 1.030e-01 S→L 9.420e-03 8.919e-03 5.006e-04 1.056e+00 5.180e-01 I→R 8.924e-04 4.054e-04 4.870e-04 2.201e+00 1.629e-02 H→L 1.719e-03 1.267e-03 4.518e-04 1.357e+00 1.492e-01 Y→H 5.817e-03 5.397e-03 4.200e-04 1.078e+00 4.928e-01 T→P 5.123e-03 4.713e-03 4.101e-04 1.087e+00 4.753e-01 R→T 2.314e-03 1.976e-03 3.372e-04 1.171e+00 3.812e-01 H→D 1.785e-03 1.470e-03 3.152e-04 1.214e+00 3.502e-01 K→I 7.272e-04 4.561e-04 2.711e-04 1.594e+00 1.874e-01 L→W 1.025e-03 8.362e-04 1.884e-04 1.225e+00 4.900e-01 L→S 4.065e-03 3.902e-03 1.633e-04 1.042e+00 7.789e-01 E→V 2.347e-03 2.230e-03 1.169e-04 1.052e+00 8.076e-01 L→G 9.916e-05 0.000e+00 9.916e-05 inf 0.000e+00 A→F 9.916e-05 0.000e+00 9.916e-05 inf 0.000e+00 T→K 2.347e-03 2.255e-03 9.156e-05 1.041e+00 8.621e-01 G→L 9.916e-05 2.534e-05 7.382e-05 3.913e+00 4.410e-01 G→K 6.610e-05 0.000e+00 6.610e-05 inf 0.000e+00 A→C 6.610e-05 0.000e+00 6.610e-05 inf 0.000e+00 S→I 2.512e-03 2.458e-03 5.411e-05 1.022e+00 9.452e-01 R→E 9.916e-05 5.068e-05 4.848e-05 1.957e+00 7.552e-01 S→H 6.610e-05 2.534e-05 4.077e-05 2.609e+00 8.030e-01 F→T 6.610e-05 2.534e-05 4.077e-05 2.609e+00 8.030e-01 D→F 6.610e-05 2.534e-05 4.077e-05 2.609e+00 8.030e-01 A→I 6.610e-05 2.534e-05 4.077e-05 2.609e+00 8.030e-01 W→F 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 V→Q 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 V→P 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 T→H 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 R→N 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 P→F 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 N→V 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 N→G 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 M→N 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 I→Y 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 I→P 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 H→T 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 H→A 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 G→T 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 F→A 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 D→I 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 D→C 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 C→V 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 A→Y 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 A→N 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 A→K 6.610e-05 5.068e-05 1.543e-05 1.304e+00 1.000e+00 W→K 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 S→V 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 R→D 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 R→A 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 Q→W 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 Q→G 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 P→V 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 I→A 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 F→N 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 F→H 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 F→G 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 E→M 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 D→Q 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 C→H 3.305e-05 2.534e-05 7.713e-06 1.304e+00 1.000e+00 A→L 6.610e-05 7.602e-05 -9.912e-06 8.696e-01 1.000e+00 S→R 6.016e-03 6.031e-03 -1.513e-05 9.975e-01 1.000e+00 L→Y 3.305e-05 5.068e-05 -1.763e-05 6.522e-01 1.000e+00 Y→T 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 Y→R 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 Y→M 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 Y→I 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 W→P 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 W→E 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 V→T 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 V→S 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 T→L 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 T→G 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 T→D 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 R→Y 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 R→F 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 Q→S 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 Q→N 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 Q→D 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 P→I 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 P→G 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 P→D 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 M→S 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 M→Q 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 L→T 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 L→D 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 K→V 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 K→L 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 K→D 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 K→A 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 G→Q 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 G→N 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 F→D 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 E→W 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 E→S 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 E→R 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 D→R 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 C→Q 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 C→K 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 A→Q 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 Y→V 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 Y→G 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 W→Q 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 T→E 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 S→D 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 Q→Y 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 N→E 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 L→C 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 H→C 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 E→T 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 E→N 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 E→L 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 A→M 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 L→A 3.305e-05 1.014e-04 -6.830e-05 3.261e-01 5.617e-01 A→R 0.000e+00 7.602e-05 -7.602e-05 0.000e+00 0.000e+00 D→S 0.000e+00 1.014e-04 -1.014e-04 0.000e+00 0.000e+00 Y→L 0.000e+00 1.267e-04 -1.267e-04 0.000e+00 0.000e+00 R→M 5.619e-04 7.348e-04 -1.729e-04 7.647e-01 4.663e-01 D→A 1.983e-03 2.204e-03 -2.213e-04 8.996e-01 5.859e-01 S→Y 2.413e-03 2.661e-03 -2.478e-04 9.069e-01 5.730e-01 T→N 2.644e-03 2.939e-03 -2.951e-04 8.996e-01 5.129e-01 K→M 6.941e-04 1.115e-03 -4.208e-04 6.226e-01 9.046e-02 D→N 1.458e-02 1.500e-02 -4.245e-04 9.717e-01 6.717e-01 R→I 4.958e-04 9.375e-04 -4.418e-04 5.288e-01 4.488e-02 P→H 2.347e-03 2.863e-03 -5.166e-04 8.196e-01 2.136e-01 F→L 9.453e-03 1.001e-02 -5.559e-04 9.445e-01 4.861e-01 H→N 1.256e-03 1.824e-03 -5.684e-04 6.884e-01 7.362e-02 R→Q 3.087e-02 3.147e-02 -6.000e-04 9.809e-01 6.730e-01 I→T 1.249e-02 1.310e-02 -6.064e-04 9.537e-01 5.055e-01 H→Y 5.586e-03 6.233e-03 -6.475e-04 8.961e-01 2.942e-01 N→H 1.851e-03 2.509e-03 -6.576e-04 7.378e-01 7.950e-02 N→T 1.752e-03 2.534e-03 -7.821e-04 6.913e-01 3.400e-02 P→Q 1.917e-03 2.711e-03 -7.942e-04 7.071e-01 3.818e-02 Q→L 1.157e-03 1.951e-03 -7.943e-04 5.929e-01 1.136e-02 K→T 1.983e-03 2.813e-03 -8.295e-04 7.051e-01 3.313e-02 F→Y 5.619e-04 1.520e-03 -9.584e-04 3.696e-01 1.537e-04 G→A 5.156e-03 6.259e-03 -1.103e-03 8.238e-01 6.376e-02 Y→F 8.263e-04 1.976e-03 -1.150e-03 4.181e-01 8.555e-05 Q→K 2.248e-03 3.446e-03 -1.199e-03 6.522e-01 4.237e-03 E→A 2.215e-03 3.522e-03 -1.308e-03 6.287e-01 1.832e-03 P→L 2.370e-02 2.516e-02 -1.463e-03 9.419e-01 2.307e-01 P→T 4.363e-03 5.904e-03 -1.541e-03 7.390e-01 5.887e-03 I→L 1.223e-03 3.041e-03 -1.818e-03 4.022e-01 3.539e-07 H→Q 3.371e-03 5.245e-03 -1.874e-03 6.428e-01 2.423e-04 M→T 6.082e-03 8.083e-03 -2.001e-03 7.524e-01 2.216e-03 N→D 4.330e-03 6.385e-03 -2.056e-03 6.781e-01 3.003e-04 M→L 1.157e-03 3.345e-03 -2.188e-03 3.459e-01 1.911e-09 K→E 7.536e-03 9.730e-03 -2.194e-03 7.745e-01 2.347e-03 K→Q 1.520e-03 3.725e-03 -2.204e-03 4.082e-01 2.351e-08 S→C 3.239e-03 5.448e-03 -2.209e-03 5.946e-01 1.543e-05 K→N 4.660e-03 6.918e-03 -2.257e-03 6.737e-01 1.312e-04 I→M 3.504e-03 5.777e-03 -2.274e-03 6.064e-01 1.663e-05 M→I 3.669e-03 6.132e-03 -2.463e-03 5.983e-01 5.498e-06 L→I 9.255e-04 3.573e-03 -2.647e-03 2.590e-01 1.980e-13 L→M 1.289e-03 4.029e-03 -2.740e-03 3.200e-01 3.520e-12 E→G 5.487e-03 8.337e-03 -2.850e-03 6.582e-01 9.324e-06 L→F 8.395e-03 1.130e-02 -2.906e-03 7.429e-01 1.534e-04 T→I 1.044e-02 1.335e-02 -2.909e-03 7.822e-01 5.651e-04 Q→E 1.917e-03 4.916e-03 -2.999e-03 3.900e-01 2.248e-11 E→Q 3.239e-03 6.994e-03 -3.754e-03 4.632e-01 8.250e-12 H→R 7.503e-03 1.135e-02 -3.849e-03 6.609e-01 2.742e-07 P→A 2.677e-03 6.664e-03 -3.987e-03 4.017e-01 2.503e-14 S→A 6.280e-04 4.916e-03 -4.288e-03 1.278e-01 2.087e-28 A→G 2.347e-03 6.740e-03 -4.393e-03 3.482e-01 1.205e-17 V→L 5.255e-03 9.958e-03 -4.703e-03 5.277e-01 2.247e-12 Q→H 3.702e-03 8.615e-03 -4.913e-03 4.297e-01 2.819e-16 M→V 6.412e-03 1.163e-02 -5.218e-03 5.513e-01 8.573e-13 D→E 3.768e-03 9.046e-03 -5.278e-03 4.165e-01 6.374e-18 T→M 1.048e-02 1.586e-02 -5.385e-03 6.605e-01 1.070e-09 S→T 1.752e-03 7.374e-03 -5.622e-03 2.376e-01 1.793e-28 A→S 2.611e-03 8.286e-03 -5.675e-03 3.151e-01 3.937e-24 R→K 2.248e-03 8.159e-03 -5.912e-03 2.755e-01 2.019e-27 L→V 5.090e-03 1.117e-02 -6.084e-03 4.555e-01 1.176e-18 V→M 1.226e-02 1.845e-02 -6.184e-03 6.647e-01 8.492e-11 T→S 1.520e-03 8.083e-03 -6.563e-03 1.881e-01 5.156e-37 S→G 2.545e-03 9.122e-03 -6.577e-03 2.790e-01 4.104e-30 E→D 3.900e-03 1.052e-02 -6.615e-03 3.709e-01 1.397e-24 S→N 4.231e-03 1.178e-02 -7.552e-03 3.591e-01 1.244e-28 N→S 9.453e-03 1.713e-02 -7.676e-03 5.519e-01 3.821e-18 K→R 3.471e-03 1.133e-02 -7.856e-03 3.064e-01 1.547e-33 P→S 1.041e-02 1.832e-02 -7.909e-03 5.683e-01 7.717e-18 Q→R 6.247e-03 1.432e-02 -8.070e-03 4.363e-01 1.955e-25 V→A 5.057e-03 1.460e-02 -9.538e-03 3.465e-01 7.651e-37 A→V 1.689e-02 2.742e-02 -1.053e-02 6.160e-01 2.864e-20 T→A 5.255e-03 1.926e-02 -1.400e-02 2.729e-01 2.234e-63 A→T 1.722e-02 3.264e-02 -1.542e-02 5.276e-01 2.435e-37 I→V 3.041e-03 2.374e-02 -2.070e-02 1.281e-01 4.525e-132 V→I 4.693e-03 2.792e-02 -2.323e-02 1.681e-01 8.738e-134

Statistics for 117 pairs of forward vesus reverse amino acid changes among pathogenic mutations Amino acid type changes that never appear in pathogenic mutations are excluded. Mutation Probability of forward mutation Probability of reverse mutation Difference in probability Rate ratio (probability for forward mutations divided by that of reverse mutation) P-value of rate ratio test R→Q 3.087e-02 6.247e-03 2.462e-02 4.942e+00 2.220e-16 R→W 3.209e-02 8.726e-03 2.337e-02 3.678e+00 2.220e-16 R→H 2.819e-02 7.503e-03 2.069e-02 3.758e+00 2.220e-16 R→C 3.543e-02 1.663e-02 1.881e-02 2.131e+00 2.220e-16 A→V 1.689e-02 5.057e-03 1.183e-02 3.340e+00 2.220e-16 D→N 1.458e-02 4.330e-03 1.025e-02 3.366e+00 2.220e-16 G→V 1.570e-02 5.586e-03 1.011e-02 2.811e+00 2.220e-16 V→M 1.226e-02 6.412e-03 5.850e-03 1.912e+00 8.304e-14 R→P 1.312e-02 7.734e-03 5.388e-03 1.697e+00 8.900e-11 S→L 9.420e-03 4.065e-03 5.354e-03 2.317e+00 6.661e-16 T→M 1.048e-02 6.082e-03 4.396e-03 1.723e+00 3.005e-09 D→Y 6.941e-03 3.173e-03 3.768e-03 2.188e+00 6.351e-11 C→F 6.809e-03 3.272e-03 3.537e-03 2.081e+00 8.692e-10 Q→P 4.793e-03 1.917e-03 2.876e-03 2.500e+00 8.783e-10 G→A 5.156e-03 2.347e-03 2.809e-03 2.197e+00 1.699e-08 D→V 5.784e-03 3.437e-03 2.347e-03 1.683e+00 2.531e-05 V→I 4.693e-03 3.041e-03 1.653e-03 1.543e+00 1.309e-03 I→F 3.371e-03 1.719e-03 1.653e-03 1.962e+00 6.865e-05 V→F 4.363e-03 2.909e-03 1.454e-03 1.500e+00 3.646e-03 E→Q 3.239e-03 1.917e-03 1.322e-03 1.690e+00 1.704e-03 H→P 3.669e-03 2.347e-03 1.322e-03 1.563e+00 3.722e-03 T→N 2.644e-03 1.752e-03 8.924e-04 1.509e+00 2.380e-02 S→F 8.660e-03 7.800e-03 8.594e-04 1.110e+00 2.626e-01 T→P 5.123e-03 4.363e-03 7.602e-04 1.174e+00 1.940e-01 R→S 6.544e-03 6.016e-03 5.288e-04 1.088e+00 4.416e-01 I→L 1.223e-03 9.255e-04 2.975e-04 1.321e+00 3.211e-01 S→T 1.752e-03 1.520e-03 2.314e-04 1.152e+00 5.467e-01 V→L 5.255e-03 5.090e-03 1.653e-04 1.032e+00 8.212e-01 L→M 1.289e-03 1.157e-03 1.322e-04 1.114e+00 7.275e-01 R→E 9.916e-05 0.000e+00 9.916e-05 inf 0.000e+00 A→F 9.916e-05 3.305e-05 6.610e-05 3.000e+00 6.250e-01 D→F 6.610e-05 0.000e+00 6.610e-05 inf 0.000e+00 A→L 6.610e-05 3.305e-05 3.305e-05 2.000e+00 1.000e+00 A→I 6.610e-05 3.305e-05 3.305e-05 2.000e+00 1.000e+00 S→V 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 R→N 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 R→D 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 R→A 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 Q→W 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 Q→G 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 P→F 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 N→V 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 N→G 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 L→Y 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 I→Y 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 H→A 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 E→M 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 D→Q 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 D→I 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 D→C 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 C→V 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 A→Y 3.305e-05 0.000e+00 3.305e-05 inf 0.000e+00 G→L 9.916e-05 9.916e-05 0.000e+00 1.000e+00 1.000e+00 P→V 3.305e-05 3.305e-05 0.000e+00 1.000e+00 1.000e+00 H→T 3.305e-05 3.305e-05 0.000e+00 1.000e+00 1.000e+00 T→G 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 Q→V 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 P→I 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 N→M 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 N→F 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 N→A 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 K→W 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 H→F 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 H→C 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 G→F 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 F→W 0.000e+00 3.305e-05 -3.305e-05 0.000e+00 0.000e+00 G→W 2.347e-03 2.413e-03 -6.610e-05 9.726e-01 9.336e-01 T→F 0.000e+00 6.610e-05 -6.610e-05 0.000e+00 0.000e+00 K→G 0.000e+00 6.610e-05 -6.610e-05 0.000e+00 0.000e+00 K→A 0.000e+00 6.610e-05 -6.610e-05 0.000e+00 0.000e+00 H→S 0.000e+00 6.610e-05 -6.610e-05 0.000e+00 0.000e+00 C→A 0.000e+00 6.610e-05 -6.610e-05 0.000e+00 0.000e+00 D→E 3.768e-03 3.900e-03 -1.322e-04 9.661e-01 8.439e-01 S→Y 2.413e-03 2.545e-03 -1.322e-04 9.481e-01 8.066e-01 I→M 3.504e-03 3.669e-03 -1.653e-04 9.550e-01 7.861e-01 K→I 7.272e-04 8.924e-04 -1.653e-04 8.148e-01 5.682e-01 H→Y 5.586e-03 5.817e-03 -2.314e-04 9.602e-01 7.467e-01 F→Y 5.619e-04 8.263e-04 -2.644e-04 6.800e-01 2.800e-01 H→Q 3.371e-03 3.702e-03 -3.305e-04 9.107e-01 5.385e-01 N→Y 1.785e-03 2.148e-03 -3.636e-04 8.308e-01 3.594e-01 K→T 1.983e-03 2.347e-03 -3.636e-04 8.451e-01 3.824e-01 R→I 4.958e-04 8.924e-04 -3.966e-04 5.556e-01 8.843e-02 H→L 1.719e-03 2.148e-03 -4.297e-04 8.000e-01 2.672e-01 L→W 1.025e-03 1.454e-03 -4.297e-04 7.045e-01 1.654e-01 S→I 2.512e-03 3.008e-03 -4.958e-04 8.352e-01 2.786e-01 H→N 1.256e-03 1.851e-03 -5.949e-04 6.786e-01 7.898e-02 K→Q 1.520e-03 2.248e-03 -7.272e-04 6.765e-01 4.872e-02 C→W 4.396e-03 5.388e-03 -9.916e-04 8.160e-01 9.171e-02 L→F 8.395e-03 9.453e-03 -1.058e-03 8.881e-01 1.821e-01 S→P 9.222e-03 1.041e-02 -1.190e-03 8.857e-01 1.509e-01 R→T 2.314e-03 3.537e-03 -1.223e-03 6.542e-01 6.646e-03 R→K 2.248e-03 3.471e-03 -1.223e-03 6.476e-01 6.038e-03 E→V 2.347e-03 3.603e-03 -1.256e-03 6.514e-01 5.668e-03 S→W 1.190e-03 2.446e-03 -1.256e-03 4.865e-01 3.713e-04 C→Y 1.758e-02 1.897e-02 -1.388e-03 9.268e-01 2.176e-01 E→A 2.215e-03 3.801e-03 -1.587e-03 5.826e-01 4.616e-04 C→G 4.627e-03 6.379e-03 -1.752e-03 7.254e-01 4.308e-03 R→L 9.122e-03 1.091e-02 -1.785e-03 8.364e-01 3.124e-02 N→I 3.107e-03 4.925e-03 -1.818e-03 6.309e-01 5.063e-04 S→A 6.280e-04 2.611e-03 -1.983e-03 2.405e-01 7.127e-10 T→I 1.044e-02 1.249e-02 -2.049e-03 8.360e-01 2.052e-02 Q→L 1.157e-03 3.239e-03 -2.082e-03 3.571e-01 4.292e-08 K→M 6.941e-04 2.843e-03 -2.148e-03 2.442e-01 1.601e-10 K→N 4.660e-03 7.172e-03 -2.512e-03 6.498e-01 6.959e-05 R→M 5.619e-04 3.636e-03 -3.074e-03 1.545e-01 7.387e-18 S→C 3.239e-03 6.379e-03 -3.140e-03 5.078e-01 2.720e-08 H→D 1.785e-03 5.751e-03 -3.966e-03 3.103e-01 6.629e-16 D→A 1.983e-03 6.677e-03 -4.693e-03 2.970e-01 3.752e-19 S→N 4.231e-03 9.453e-03 -5.222e-03 4.476e-01 5.623e-15 P→A 2.677e-03 9.850e-03 -7.172e-03 2.718e-01 2.792e-30 E→G 5.487e-03 1.487e-02 -9.387e-03 3.689e-01 3.324e-31 D→G 9.651e-03 1.993e-02 -1.028e-02 4.842e-01 1.193e-25 T→A 5.255e-03 1.722e-02 -1.196e-02 3.052e-01 8.453e-46 P→L 2.370e-02 3.788e-02 -1.418e-02 6.257e-01 2.280e-23 S→G 2.545e-03 1.798e-02 -1.544e-02 1.415e-01 1.576e-87 K→E 7.536e-03 2.568e-02 -1.815e-02 2.934e-01 1.272e-70 R→G 1.157e-02 3.851e-02 -2.694e-02 3.004e-01 2.587e-102

Statistics for 133 pairs of forward vesus reverse amino acid changes among benign mutations Amino acid type changes that never appear in pathogenic mutations are excluded. Mutation Probability of forward mutation Probability of reverse mutation Difference in probability Rate ratio (probability for forward mutations divided by that of reverse mutation) P-value of rate ratio test R→Q 3.147e-02 1.432e-02 1.715e-02 2.198e+00 2.220e-16 R→H 2.724e-02 1.135e-02 1.589e-02 2.400e+00 2.220e-16 R→C 1.974e-02 5.245e-03 1.449e-02 3.763e+00 2.220e-16 P→L 2.516e-02 1.181e-02 1.335e-02 2.131e+00 2.220e-16 A→V 2.742e-02 1.460e-02 1.282e-02 1.878e+00 2.220e-16 R→W 1.629e-02 3.953e-03 1.234e-02 4.122e+00 2.220e-16 D→N 1.500e-02 6.385e-03 8.615e-03 2.349e+00 2.220e-16 T→M 1.586e-02 8.083e-03 7.779e-03 1.962e+00 2.220e-16 V→M 1.845e-02 1.163e-02 6.816e-03 1.586e+00 5.551e-15 S→L 8.919e-03 3.902e-03 5.017e-03 2.286e+00 2.220e-16 V→I 2.792e-02 2.374e-02 4.181e-03 1.176e+00 2.794e-04 S→F 6.867e-03 3.953e-03 2.914e-03 1.737e+00 2.867e-08 S→C 5.448e-03 3.243e-03 2.204e-03 1.680e+00 3.052e-06 E→Q 6.994e-03 4.916e-03 2.078e-03 1.423e+00 1.804e-04 D→Y 2.838e-03 8.869e-04 1.951e-03 3.200e+00 1.365e-10 G→V 5.245e-03 3.471e-03 1.774e-03 1.511e+00 1.900e-04 E→G 8.337e-03 6.689e-03 1.647e-03 1.246e+00 8.530e-03 D→V 2.661e-03 1.115e-03 1.546e-03 2.386e+00 6.256e-07 R→L 4.840e-03 3.345e-03 1.495e-03 1.447e+00 1.216e-03 S→I 2.458e-03 1.014e-03 1.444e-03 2.425e+00 1.220e-06 L→F 1.130e-02 1.001e-02 1.292e-03 1.129e+00 8.462e-02 S→Y 2.661e-03 1.470e-03 1.191e-03 1.810e+00 2.881e-04 K→N 6.918e-03 5.803e-03 1.115e-03 1.192e+00 5.485e-02 V→F 2.331e-03 1.470e-03 8.615e-04 1.586e+00 6.852e-03 I→F 2.052e-03 1.216e-03 8.362e-04 1.687e+00 4.650e-03 H→Y 6.233e-03 5.397e-03 8.362e-04 1.155e+00 1.352e-01 E→A 3.522e-03 2.711e-03 8.108e-04 1.299e+00 4.788e-02 L→M 4.029e-03 3.345e-03 6.842e-04 1.205e+00 1.273e-01 E→V 2.230e-03 1.571e-03 6.588e-04 1.419e+00 4.087e-02 K→T 2.813e-03 2.255e-03 5.575e-04 1.247e+00 1.374e-01 R→I 9.375e-04 4.054e-04 5.321e-04 2.312e+00 5.486e-03 N→Y 1.216e-03 7.855e-04 4.308e-04 1.548e+00 7.116e-02 T→N 2.939e-03 2.534e-03 4.054e-04 1.160e+00 3.074e-01 G→W 9.629e-04 6.335e-04 3.294e-04 1.520e+00 1.299e-01 K→M 1.115e-03 8.108e-04 3.041e-04 1.375e+00 2.067e-01 K→Q 3.725e-03 3.446e-03 2.787e-04 1.081e+00 5.523e-01 Q→L 1.951e-03 1.672e-03 2.787e-04 1.167e+00 4.031e-01 Q→P 2.965e-03 2.711e-03 2.534e-04 1.093e+00 5.477e-01 P→A 6.664e-03 6.411e-03 2.534e-04 1.040e+00 6.920e-01 T→I 1.335e-02 1.310e-02 2.534e-04 1.019e+00 7.806e-01 L→W 8.362e-04 6.588e-04 1.774e-04 1.269e+00 4.350e-01 K→I 4.561e-04 3.041e-04 1.520e-04 1.500e+00 3.616e-01 S→W 6.335e-04 5.828e-04 5.068e-05 1.087e+00 8.854e-01 D→S 1.014e-04 5.068e-05 5.068e-05 2.000e+00 6.875e-01 Q→Y 5.068e-05 0.000e+00 5.068e-05 inf 0.000e+00 E→L 5.068e-05 0.000e+00 5.068e-05 inf 0.000e+00 A→M 5.068e-05 0.000e+00 5.068e-05 inf 0.000e+00 R→E 5.068e-05 2.534e-05 2.534e-05 2.000e+00 1.000e+00 H→C 5.068e-05 2.534e-05 2.534e-05 2.000e+00 1.000e+00 T→G 2.534e-05 0.000e+00 2.534e-05 inf 0.000e+00 R→F 2.534e-05 0.000e+00 2.534e-05 inf 0.000e+00 P→V 2.534e-05 0.000e+00 2.534e-05 inf 0.000e+00 P→I 2.534e-05 0.000e+00 2.534e-05 inf 0.000e+00 K→V 2.534e-05 0.000e+00 2.534e-05 inf 0.000e+00 K→L 2.534e-05 0.000e+00 2.534e-05 inf 0.000e+00 K→D 2.534e-05 0.000e+00 2.534e-05 inf 0.000e+00 G→L 2.534e-05 0.000e+00 2.534e-05 inf 0.000e+00 E→S 2.534e-05 0.000e+00 2.534e-05 inf 0.000e+00 E→M 2.534e-05 0.000e+00 2.534e-05 inf 0.000e+00 R→T 1.976e-03 1.951e-03 2.534e-05 1.013e+00 1.000e+00 E→T 5.068e-05 5.068e-05 0.000e+00 1.000e+00 1.000e+00 E→N 5.068e-05 5.068e-05 0.000e+00 1.000e+00 1.000e+00 T→L 2.534e-05 2.534e-05 0.000e+00 1.000e+00 1.000e+00 S→V 2.534e-05 2.534e-05 0.000e+00 1.000e+00 1.000e+00 R→Y 2.534e-05 2.534e-05 0.000e+00 1.000e+00 1.000e+00 R→D 2.534e-05 2.534e-05 0.000e+00 1.000e+00 1.000e+00 Q→G 2.534e-05 2.534e-05 0.000e+00 1.000e+00 1.000e+00 E→W 2.534e-05 2.534e-05 0.000e+00 1.000e+00 1.000e+00 D→Q 2.534e-05 2.534e-05 0.000e+00 1.000e+00 1.000e+00 D→F 2.534e-05 2.534e-05 0.000e+00 1.000e+00 1.000e+00 A→I 2.534e-05 2.534e-05 0.000e+00 1.000e+00 1.000e+00 H→L 1.267e-03 1.292e-03 -2.534e-05 9.804e-01 1.000e+00 Q→W 2.534e-05 5.068e-05 -2.534e-05 5.000e-01 1.000e+00 K→A 2.534e-05 5.068e-05 -2.534e-05 5.000e-01 1.000e+00 T→Y 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 T→V 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 T→F 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 S→Q 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 S→M 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 Q→M 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 Q→C 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 Q→A 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 P→W 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 N→Q 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 N→G 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 N→F 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 M→Y 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 K→W 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 K→C 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 I→Y 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 H→S 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 H→F 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 G→P 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 G→F 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 D→T 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 D→P 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 D→L 0.000e+00 2.534e-05 -2.534e-05 0.000e+00 0.000e+00 A→L 7.602e-05 1.014e-04 -2.534e-05 7.500e-01 1.000e+00 R→A 2.534e-05 7.602e-05 -5.068e-05 3.333e-01 6.250e-01 V→Y 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 G→Y 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 C→L 0.000e+00 5.068e-05 -5.068e-05 0.000e+00 0.000e+00 L→Y 5.068e-05 1.267e-04 -7.602e-05 4.000e-01 4.531e-01 R→M 7.348e-04 8.362e-04 -1.014e-04 8.788e-01 7.035e-01 C→F 1.216e-03 1.419e-03 -2.027e-04 8.571e-01 4.926e-01 C→W 1.090e-03 1.318e-03 -2.281e-04 8.269e-01 4.119e-01 I→M 5.777e-03 6.132e-03 -3.547e-04 9.421e-01 5.488e-01 N→I 1.343e-03 1.774e-03 -4.308e-04 7.571e-01 1.488e-01 F→Y 1.520e-03 1.976e-03 -4.561e-04 7.692e-01 1.476e-01 G→A 6.259e-03 6.740e-03 -4.814e-04 9.286e-01 4.268e-01 R→S 5.499e-03 6.031e-03 -5.321e-04 9.118e-01 3.485e-01 I→L 3.041e-03 3.573e-03 -5.321e-04 8.511e-01 2.157e-01 H→N 1.824e-03 2.509e-03 -6.842e-04 7.273e-01 4.646e-02 S→T 7.374e-03 8.083e-03 -7.095e-04 9.122e-01 2.743e-01 C→G 1.140e-03 1.900e-03 -7.602e-04 6.000e-01 7.847e-03 H→P 1.850e-03 2.863e-03 -1.014e-03 6.460e-01 4.118e-03 T→P 4.713e-03 5.904e-03 -1.191e-03 7.983e-01 2.451e-02 V→L 9.958e-03 1.117e-02 -1.216e-03 8.912e-01 1.036e-01 D→G 6.943e-03 8.235e-03 -1.292e-03 8.431e-01 4.097e-02 D→A 2.204e-03 3.674e-03 -1.470e-03 6.000e-01 1.698e-04 D→E 9.046e-03 1.052e-02 -1.470e-03 8.602e-01 4.015e-02 R→P 4.029e-03 5.828e-03 -1.799e-03 6.913e-01 3.736e-04 H→D 1.470e-03 4.029e-03 -2.559e-03 3.648e-01 4.643e-12 C→Y 4.561e-03 7.196e-03 -2.635e-03 6.338e-01 1.581e-06 R→K 8.159e-03 1.133e-02 -3.167e-03 7.204e-01 7.435e-06 H→Q 5.245e-03 8.615e-03 -3.370e-03 6.088e-01 1.420e-08 S→A 4.916e-03 8.286e-03 -3.370e-03 5.933e-01 6.109e-09 S→N 1.178e-02 1.713e-02 -5.347e-03 6.879e-01 4.540e-10 R→G 9.451e-03 1.490e-02 -5.448e-03 6.344e-01 4.159e-12 S→G 9.122e-03 1.568e-02 -6.563e-03 5.816e-01 1.095e-16 S→P 8.691e-03 1.832e-02 -9.629e-03 4.744e-01 8.397e-32 K→E 9.730e-03 2.030e-02 -1.057e-02 4.794e-01 2.625e-34 T→A 1.926e-02 3.264e-02 -1.338e-02 5.901e-01 1.126e-31

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