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GPCR

NameB2 bradykinin receptor
SpeciesCavia porcellus (Guinea pig)
GeneBDKRB2
SynonymB2R
BK-2 receptor
DiseaseN/A for non-human GPCRs
Length372
Amino acid sequenceMFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGHNVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWARSSSEGTPPGLL
UniProtO70526
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4111
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL376866
Molecular formulaC35H47Cl2N6O5S+
IUPAC name[(3S)-3-amino-4-[4-[1-[[2,4-dichloro-3-[(2,4-dimethylquinolin-8-yl)oxymethyl]phenyl]sulfonylamino]cyclopentanecarbonyl]piperazin-1-yl]-4-oxobutyl]-trimethylazanium
Molecular weight734.758
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP4.0
SynonymsBDBM50411264
Inchi KeyHJPYQPWVTVOICU-NDEPHWFRSA-N
Inchi IDInChI=1S/C35H47Cl2N6O5S/c1-23-21-24(2)39-32-25(23)9-8-10-29(32)48-22-26-27(36)11-12-30(31(26)37)49(46,47)40-35(14-6-7-15-35)34(45)42-18-16-41(17-19-42)33(44)28(38)13-20-43(3,4)5/h8-12,21,28,40H,6-7,13-20,22,38H2,1-5H3/q+1/t28-/m0/s1
PubChem CID16105742
ChEMBLCHEMBL376866
IUPHARN/A
BindingDB50411264
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity45.0 %PMID17266207ChEMBL
Activity87.0 %PMID17266207ChEMBL

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