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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	C-C chemokine receptor type 1
Species	Homo sapiens (Human)
Gene	CCR1
Synonym	macrophage inflammatory protein-1 alpha receptor MIP-1alpha-R MIP-1alpha/RANTES MIP-1alphaR MIP1aR RANTES-R Macrophage inflammatory protein 1-alpha receptor LD78 receptor HM145 C-C CKR-1 CC CKR1 CC-CKR-1 CCR-1 CCR1 CD191 CKR1 CMKBR1 [ Show all ]
Disease	Autoimmune diabetes Rheumatoid arthritis Chronic obstructive pulmonary disease
Length	355
Amino acid sequence	METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
UniProt	P32246
Protein Data Bank	N/A
GPCR-HGmod model	P32246
3D structure model	This predicted structure model is from GPCR-EXP P32246.
BioLiP	N/A
Therapeutic Target Database	T16016
ChEMBL	CHEMBL2413
IUPHAR	58
DrugBank	N/A

Ligand

Name	128143-88-4
Molecular formula	C15H11N3O
IUPAC name	2,6-dipyridin-2-yl-1H-pyridin-4-one
Molecular weight	249.273
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	1.3
Synonyms	KB-280983 Z2460 1'H-[2,2',6',2'']Terpyridin-4'-one 2,6-?Bis(2-?pyridyl)?-?4(1H)-pyridone 4'-HYDROXY-2,2':6',2''-TERPYRIDINE AJ-22002 CTK0H0167 HRORSVNZQWCZTD-UHFFFAOYSA-N MolPort-003-934-494 [2,2':6',2''-Terpyridin]-4'(1'H)-one 1'H-[2,2';6',2'']terpyridin-4'-one 2,6-Bis(2-pyridyl)-4(1H)-pyridone,98% 6-(pyridin-2-yl)-[2,2'-bipyridine]-4-ol ANW-19055 J-005568 SC-70393 2,6-bis-pyridyl-4-(1H)-pyridone ACMC-209bep KS-00000USR ZB013138 1'H-[2,2';6',2 '']terpyridine-4'-one 2,6-Bis(2-pyridyl)-4(1H)-pyridone 4-Terpyridone AKOS015912996 CTK0H4325 I14-41476 MolPort-020-169-847 [2,2':6',2''-Terpyridin]-4'-ol 1'H-[2,2';6',2'']terpyridine-4'-one 2,6-bis(pyridin-2-yl)-4(1h)-pyridone AC-27853 AX8067954 J-400598 SCHEMBL1988750 2,2':6',2''-Terpyridin-4'-ol 2,6-dipyridin-2-yl-1H-pyridin-4-one ACMC-20m41v CHEMBL2205804 KS-00001KN4 ZINC403259 1'H-[2,2';6',2'']terpyridin-4'-on 2,6-Bis(2-pyridyl)-4(1H)-pyridone, 98% AKOS015914629 EOS227 I14-48284 OC1=CC(=NC(=C1)C1=CC=CC=N1)C1=NC=CC=C1 [2,2,6,2-terpyridin]-4(1H)-one 101003-65-0 2,6-Bis(pyridine-2-yl)pyridine-4(1H)-one AC1LDIYW BDBM50401356 [ Show all ]
Inchi Key	HRORSVNZQWCZTD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H11N3O/c19-11-9-14(12-5-1-3-7-16-12)18-15(10-11)13-6-2-4-8-17-13/h1-10H,(H,18,19)
PubChem CID	619353
ChEMBL	CHEMBL2205804
IUPHAR	N/A
BindingDB	50401356
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID22957890	BindingDB,ChEMBL
EC50	>1000000.0 nM	PMID22957890	ChEMBL

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