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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R GnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30969
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3066
IUPHAR	256
DrugBank	N/A

Ligand

Name	CHEMBL405961
Molecular formula	C57H83ClN16O14
IUPAC name	(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamidobutanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-4-[[(3S,6R,9R,17S)-17-[(2R)-2-[[(2S)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-6-[3-(diaminomethylideneamino)propyl]-3-(2-methylpropyl)-2,5,8,11-tetraoxo-1,4,7,12-tetrazacycloheptadec-9-yl]amino]-4-oxobutanoic acid
Molecular weight	1251.84
Hydrogen bond acceptor	16
Hydrogen bond donor	14
XlogP	-1.2
Synonyms	BDBM50085706 Cyclo (5-8) [Ac-D Nal, Cpa, D Pal, Asp, Asp, D Arg, Leu, Lys, Pro, D Ala]GnRH
Inchi Key	ARXCGKHHJCJYBQ-DSKCGGKLSA-N
Inchi ID	InChI=1S/C57H83ClN16O14/c1-6-36(66-32(5)75)48(80)70-40(25-33-16-18-35(58)19-17-33)51(83)71-41(26-34-12-9-20-62-29-34)52(84)73-43(28-46(77)78)54(86)72-42-27-45(76)63-21-8-7-13-38(56(88)74-23-11-15-44(74)55(87)65-31(4)47(59)79)68-50(82)39(24-30(2)3)69-49(81)37(67-53(42)85)14-10-22-64-57(60)61/h9,12,16-20,29-31,36-44H,6-8,10-11,13-15,21-28H2,1-5H3,(H2,59,79)(H,63,76)(H,65,87)(H,66,75)(H,67,85)(H,68,82)(H,69,81)(H,70,80)(H,71,83)(H,72,86)(H,73,84)(H,77,78)(H4,60,61,64)/t31-,36-,37+,38-,39-,40-,41-,42+,43-,44+/m0/s1
PubChem CID	44378916
ChEMBL	CHEMBL405961
IUPHAR	N/A
BindingDB	50085706
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	130.0 nM	PMID10715147	BindingDB,ChEMBL

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