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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R GnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30969
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3066
IUPHAR	256
DrugBank	N/A

Ligand

Name	CHEMBL88293
Molecular formula	C24H27ClN2O2
IUPAC name	7-chloro-3-(3,5-dimethylphenyl)-4-(1-methylazepan-4-yl)oxy-1H-quinolin-2-one
Molecular weight	410.942
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.0
Synonyms	BDBM50081134 7-Chloro-3-(3,5-dimethyl-phenyl)-4-(1-methyl-azepan-4-yloxy)-1H-quinolin-2-one
Inchi Key	ACAQZLNOFLLWTO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H27ClN2O2/c1-15-11-16(2)13-17(12-15)22-23(29-19-5-4-9-27(3)10-8-19)20-7-6-18(25)14-21(20)26-24(22)28/h6-7,11-14,19H,4-5,8-10H2,1-3H3,(H,26,28)
PubChem CID	44322443
ChEMBL	CHEMBL88293
IUPHAR	N/A
BindingDB	50081134
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	300.0 nM	PMID10498220	BindingDB,ChEMBL

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