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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	NAN-190 hydrobromide
Molecular formula	C23H28BrN3O3
IUPAC name	2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindole-1,3-dione;hydrobromide
Molecular weight	474.399
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	None
Synonyms	AC1L332K CHEBI:64123 FT-0764658 MLS000859948 NCGC00094200-01 ST24039357 1H-Isoindole-1,3(2H)-dione, 2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-, monohydrobromide AX8233420 CS-5473 KB-222072 NAN 190 hydrobromide SCHEMBL4083153 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazinehydrobromide 2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindole-1,3-dione hydrobromide C23H28BrN3O3 EBD2206388 LS-84602 SR-01000075563-1 115338-32-4 2511AA AKOS016004193 CHEMBL1256701 HY-19818A MolPort-003-958-974 NCGC00261561-01 Tox21_500876 1-(2-Methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine hydrobromide 2-(4-(4-(2-METHOXYPHENYL)PIPERAZIN-1-YL)BUTYL)-ISOINDOLINE-1,3-DIONE HYDROBROMIDE B6349 CTK8B9474 KB-282405 NAN-190 SMR000326807 1-(2-Methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide 2-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione hydrobromide AC-27421 CCG-222180 EU-0100876 MFCD00078590 NAN190 hydrobromide SR-01000075563-3 115388-32-4 ANW-62583 CN-027 J-003283 N 3529 RT-014661 TX-011461 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide 2-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione hydrobromide BN0367 DTXSID5042588 LP00876 NAN-190 (hydrobromide) SR-01000075563 1-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-4-(2-methoxyphenyl)piperazin-1-ium bromide 2-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}isoindole-1,3-dione hydrobromide [ Show all ]
Inchi Key	AXRUEPFPTQYHQD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H27N3O3.BrH/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28;/h2-5,8-11H,6-7,12-17H2,1H3;1H
PubChem CID	107966
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3.4 nM	PMID9686407	PDSP

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