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Name | Gonadotropin-releasing hormone receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Gnrhr |
Synonym | luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 327 |
Amino acid sequence | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | P30969 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3066 |
IUPHAR | 256 |
DrugBank | N/A |
Name | CHEMBL416286 |
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Molecular formula | C36H39N3O2 |
IUPAC name | N-benzyl-2-(3,5-dimethylphenyl)-3-[2-[4-(4-hydroxyphenyl)butylamino]ethyl]-1H-indole-5-carboxamide |
Molecular weight | 545.727 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 4 |
XlogP | 7.4 |
Synonyms | 2-(3,5-Dimethyl-phenyl)-3-{2-[4-(4-hydroxy-phenyl)-butylamino]-ethyl}-1H-indole-5-carboxylic acid benzylamide BDBM50101176 N-benzyl-2-(3,5-dimethylphenyl)-3-[2-[4-(4-hydroxyphenyl)butylamino]ethyl]-1H-indole-5-carboxamide |
Inchi Key | AXXZDEQUAAZLGS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C36H39N3O2/c1-25-20-26(2)22-30(21-25)35-32(17-19-37-18-7-6-8-27-11-14-31(40)15-12-27)33-23-29(13-16-34(33)39-35)36(41)38-24-28-9-4-3-5-10-28/h3-5,9-16,20-23,37,39-40H,6-8,17-19,24H2,1-2H3,(H,38,41) |
PubChem CID | 44293343 |
ChEMBL | CHEMBL416286 |
IUPHAR | N/A |
BindingDB | 50101176 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
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IC50 | 24.0 nM | PMID11425546 | BindingDB,ChEMBL |
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