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GPCR

NameProteinase-activated receptor 2
SpeciesRattus norvegicus (Rat)
GeneF2rl1
Synonymcoagulation factor II (thrombin) receptor-like 1
coagulation factor II receptor-like 1
GPR11
PAR-2
PAR2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length397
Amino acid sequenceMRSLSLAWLLGGITLLAASASCNRTVNAPGPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSASVLTGKLTTVFLPVIYIIVFVIGLPSNGMALWVFFFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNDWTYGDALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKRANIAVGVSLAIWLLIFLVTIPLYVMRQTIYIPALNITTCHDVLPEEVLVGDMFSYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAMDEHSEKKRRRAIRLIITVLSMYFICFAPSNVLLVVHYFLIKSQRQSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDQARNALLCRSVRTVKRMQISLTSNKFSRKSSSYSSSSTSVKTSY
UniProtQ63645
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2429706
IUPHARN/A
DrugBankN/A

Ligand

NameFSLLRY-NH2
Molecular formulaC39H60N10O8
IUPAC name(2S)-N-[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanamide
Molecular weight796.971
Hydrogen bond acceptor10
Hydrogen bond donor11
XlogP0.6
SynonymsPhe-Ser-Leu-Leu-Arg-Tyr-NH2
(Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human)
L-Phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide
AKOS024458326
ZINC96284602
[ Show all ]
Inchi KeyKMSCNWHRNILNRJ-JNRWAQIZSA-N
Inchi IDInChI=1S/C39H60N10O8/c1-22(2)17-30(36(55)45-28(11-8-16-44-39(42)43)35(54)46-29(33(41)52)20-25-12-14-26(51)15-13-25)47-37(56)31(18-23(3)4)48-38(57)32(21-50)49-34(53)27(40)19-24-9-6-5-7-10-24/h5-7,9-10,12-15,22-23,27-32,50-51H,8,11,16-21,40H2,1-4H3,(H2,41,52)(H,45,55)(H,46,54)(H,47,56)(H,48,57)(H,49,53)(H4,42,43,44)/t27-,28-,29-,30-,31-,32-/m0/s1
PubChem CID73352412
ChEMBLCHEMBL2431725
IUPHARN/A
BindingDB50440871
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC5050000.0 nMPMID23895492BindingDB,ChEMBL

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