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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Cannabinoid receptor 2
Species	Homo sapiens (Human)
Gene	CNR2
Synonym	Peripheral cannabinoid receptor rCB2 hCB2 cannabinoid receptor 2 (macrophage) cannabinoid receptor 2 (spleen) CB-2 CB2 CB2 receptor CB2-R CX5 [ Show all ]
Disease	Immune disorder Inflammatory bowel disease Inflammatory disease Neuropathic pain Osteoporosis Pain Atopic dermatitis Rheumatoid arthritis [ Show all ]
Length	360
Amino acid sequence	MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProt	P34972
Protein Data Bank	5zty
GPCR-HGmod model	P34972
3D structure model	This structure is from PDB ID 5zty.
BioLiP	BL0438927
Therapeutic Target Database	T37693
ChEMBL	CHEMBL253
IUPHAR	57
DrugBank	BE0000095

Ligand

Name	Anandamide
Molecular formula	C22H37NO2
IUPAC name	(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
Molecular weight	347.543
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	5.4
Synonyms	BSPBio_001533 CS-0002859 HMS3649B09 MolPort-003-940-012 N-arachidonoyl ethanolamine NCGC00161195-07 5,8,11,14-eicosatetraenamide, N-(2-hydroxyethyl)- [14C]Anandamide AB1009196 Anandamide (20:4, n-6) Arachidonoylethanolamide (AEA) C22H37NO2 GTPL2364 L000111 N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide N-Arachidonoylethanolamine (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide SR-01000946635 5,8,11,14-Eicosatetraenoylethanolamide AEA; Anandamide; Arachidonic acid N-(hydroxyethyl)amide AnNH Arachidonylethanolamide, >=97.0% (TLC), oil BN0078 HMS1989M15 LS-63781 N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine NCGC00161195-05 UR5G69TJKH 74004-EP2308869A1 Anandamide (20.4, n-6) Arachidonoyl-EA C11695 D0A9PS HY-10863 N-(2-hydroxyethyl)-5,8,11,14-Eicosatetraenamide (all-Z) N-Arachidonoyl-2-hydroxyethylamide (5Z,8Z,11Z,14Z)- N-(2-Hydroxyethyl)- 5,8,11,14-eicosatetraenamide SCHEMBL43143 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (5Z,8Z,11Z,14Z)- [3H]Anandamide AC1NQZCS Anandamide (in Tocrisolvetrade mark 100) Arachidonyl ethanolamide CCG-208077 HMS1361M15 LGEQQWMQCRIYKG-DOFZRALJSA-N N-(2-Hydroxyethyl)anachidonamide NCGC00161195-03 (all-Z)-N-(2-hydroxyethyl)-5,8,11,14-eicosatetraenamide SR-01000946635-1 74004-EP2270006A1 AKOS015951333 Arachidonic acid N-(hydroxyethyl)amide BDBM22988 BRD-K42352790-001-03-8 CHEMBL15848 HMS3402M15 MFCD00153766 N-(5Z,8Z,11Z,14Z-icosatetraenoyl)-ethanolamide NCGC00161195-06 ZINC3809850 94421-68-8 anandamide (20.4,n-6) arachidonoylethanolamide C20:4 anandamide (AEA), 5Z,8Z,11Z,14Z-eicosatetraenoylethanolamide, neat oil E7Y IDI1_034003 N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide (all-Z)- N-arachidonoylaminoethan-2-ol (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)-5,8,11,14-eicosatetraenamide SMP2_000328 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)- AEA Anandamide(20:4, n-6) Arachidonylethanolamide CHEBI:2700 HMS1791M15 LMFA08040001 N-(2-hydroxyethyl)arachidonamide NCGC00161195-04 1616AH UNII-UR5G69TJKH 74004-EP2277861A1 Arachidonoyl ethanolamide BML2-B09 [ Show all ]
Inchi Key	LGEQQWMQCRIYKG-DOFZRALJSA-N
Inchi ID	InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
PubChem CID	5281969
ChEMBL	CHEMBL15848
IUPHAR	2364
BindingDB	22988
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<1000.0 nM	PMID11741470	BindingDB,ChEMBL
Ki	168.0 nM	PMID19361197	BindingDB,ChEMBL
Ki	180.0 nM	PMID19161308, PMID16682198, PMID16570929, PMID16213718	BindingDB,ChEMBL
Ki	306.0 nM	PMID10688601	BindingDB
Ki	371.0 nM	PMID23865723	BindingDB,ChEMBL
Ki	398.107 - 1995.26 nM	PMID7565624, PMID8819477, PMID7605349	IUPHAR
Log Ki	2.57 nM	PMID10882356	ChEMBL

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