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GLASS

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GPCR

Name	N-arachidonyl glycine receptor
Species	Homo sapiens (Human)
Gene	GPR18
Synonym	GPCRW G-protein coupled receptor 18 N-arachidonoyol glycine receptor NAGly receptor GPR18
Disease	N/A
Length	331
Amino acid sequence	MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProt	Q14330
Protein Data Bank	N/A
GPCR-HGmod model	Q14330
3D structure model	This predicted structure model is from GPCR-EXP Q14330.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2384898
IUPHAR	89
DrugBank	BE0002304

Ligand

Name	CHEMBL3220946
Molecular formula	C20H18N2O3S
IUPAC name	ethyl 6-oxo-5,5-diphenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate
Molecular weight	366.435
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.6
Synonyms	5,5-Diphenyl-6-oxo-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole-2-carboxylic acid ethyl ester
Inchi Key	LLWVWQYDADULBL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18N2O3S/c1-2-25-17(23)16-13-22-19(26-16)21-18(24)20(22,14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-12,16H,2,13H2,1H3
PubChem CID	21858022
ChEMBL	CHEMBL3220946
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	7.0 %	MedChemComm, (2014) 5:5:632	ChEMBL
IC50	<10000.0 nM	MedChemComm, (2014) 5:5:632	ChEMBL
Inhibition	0.0 %	MedChemComm, (2014) 5:5:632	ChEMBL

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