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GPCR

Name	Alpha-2C adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2c
Synonym	alpha2C-adrenoceptor alpha2-C4 Alpha-2CAR alpha-2C adrenoreceptor Alpha-2C adrenoceptor alpha-2C adrenergic receptor alpha-2 adrenergic receptor subtype C4 adrenergic receptor Adrenergic alpha2C- receptor class I ADRA2RL2 ADRA2L2 Adra-2c [ Show all ]
Disease	N/A for non-human GPCRs
Length	458
Amino acid sequence	MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P22086
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL314
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	haloperidol
Molecular formula	C21H23ClFNO2
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Molecular weight	375.868
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	DSSTox_RID_79117 NCGC00023875-07 4763-EP2316834A1 HMS3370H11 SCHEMBL8264 Eukystol NSC 615296 AB00052008-22 IDI1_000654 Sigaperidol gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone Oprea1_509923 ACM1189986591 KBio2_003909 Spectrum4_000570 Halidol Picroside-III Aloperidolo [Italian] KBioSS_001341 .gamma.-[4-(p-Chlorphenyl)-4-hydroxpiperidino]-p-fluorbutyrophenone STL417208 Probes1_000255 BIDD:GT0128 LNEPOXFFQSENCJ-UHFFFAOYSA- 4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone Ulcolind BRD-K67783091-003-03-6 MCULE-3693790133 4-[4-(4-Chlorophenyl)-4-hydroxy- 1-piperidinyl]-1-(4-fluorophenyl)- 1-butanone ZINC537822 Haloperido Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- N1910 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard CCRIS 1630 NCGC00015500-08 4763-EP2277872A1 Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material NCGC00015500-16 4763-EP2298776A1 Halosten (TN) HMS2089M15 Duraperidol (TN) NCGC00254503-01 61788-97-4 HMS502A16 Serenase FT-0669100 NSC-757054 AB2000375 J6292F8L3D SPBio_001236 H 1512 Peluces (TN) Aloperidin KBio2_007526 SR-01000003076 Prestwick0_000115 AOB5645 Keselan (TN) 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- Tox21_110162 R 1625 Bioperidolo (TN) Lopac0_000583 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one Vesalium Brotopon (TN) Mixidol 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one Haloperidol (JP15/USP) C21H23ClFNO2 NCGC00015500-03 4763-EP2269990A1 Haloperidol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material CHEMBL54 NCGC00015500-11 4763-EP2295061A1 Haloperidolum Dozic NCGC00016234-01 4763-EP2308870A2 NCGC00023875-05 4763-EP2311824A1 HMS2234P08 SC 170973 EINECS 200-155-6 Novo-Peridol AB00052008 I14-13404 Sernas gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone NSC757054 AC1Q77Z0 KBio2_001341 Spectrum2_001268 Haldol La Pharmakon1600-01500325 Aloperidolo KBioGR_000980 SR-01000003076-8 Prestwick3_000115 BDBM21398 Linton 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone Tox21_500583 S1920 BRD-K67783091-001-04-8 McM-JR-1625 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone W0039 Halol Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)- MolPort-000-883-311 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Haloperidol 1.0 mg/ml in Methanol CCG-36042 NCGC00015500-06 4763-EP2272973A1 Haloperidol, 1 D00136 NCGC00015500-14 4763-EP2295439A1 Halopoidol DSSTox_CID_14150 DTXSID4034150 NCGC00023875-08 5-21-02-00377 (Beilstein Handbook Reference) HMS3657I13 Serenace Eukystol (TN) NSC-170973 AB00052008_23 IN1474 Sigaperidol (TN) gamma-[4-(p-chlorophenyl)-4-hydroxypiperidino]-p-fluorobutyrophenone Pekuces AKOS000280660 KBio2_004958 Spectrum5_000788 Pms Haloperidol Aloperidon KBioSS_002395 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine SW196557-4 Probes2_000296 Biomol-NT_000035 LNEPOXFFQSENCJ-UHFFFAOYSA-N 4'-Fluoro-4-[4-hydroxy-4-(4'-chlorophenyl)piperidino]butyrophenone Uliolind BRN 0331267 MDMO-PPV 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl) -1-butanone C-35402 NCGC00015500-01 4-[4-(para-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Haloperidol Intensol CHEBI:5613 NCGC00015500-09 4763-EP2277876A1 Haloperidol, powder DB00502 NCGC00015500-17 4763-EP2305260A1 HMS1568G12 4763-EP2311801A1 HMS2091J09 Einalon S NCGC00261268-01 HSDB 3093 Serenase (TN) FT-0697842 NSC170973 AC-19691 KB-79571 SPBio_002069 Haldol Peridol Aloperidin (TN) KBio3_001316 SR-01000003076-11 Prestwick1_000115 API0002885 L000288 177716-59-5 Tox21_110162_1 R-1625 BPBio1_000144 LP00583 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone VU0239704-10 BSPBio_000130 MLS000028450 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one Haloperidol (JP15/USP/INN) CAS-52-86-8 NCGC00015500-04 4763-EP2272537A2 Haloperidol [USAN:INN:BAN:JAN] cMAP_000037 NCGC00015500-12 4763-EP2295412A1 Haloperidolum [INN-Latin] Dozic (TN) NCGC00023875-02 NCGC00023875-06 4763-EP2311837A1 HMS3261F08 SC-81035 EU-0100583 NSC 170973 AB00052008-21 I14-14165 Sernel gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone Opera_ID_446 AC250 KBio2_002390 Spectrum3_000448 Haldol Solutab Phenolic epoxy resin Aloperidolo [DCIT] KBioGR_002390 .gamma.-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone ST50319916 Prestwick_250 BG0211 Linton (TN) 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone TR-018722 SBI-0050565.P004 BRD-K67783091-001-05-5 McN-JR-1625 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) WLN: T6NTJ A3VR DF& DQ DR DG Halopal Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro- MRF-0000027 4-[4-(4-chlorophenyl)-4-hydroxypiperidyl]-1-(4-fluorophenyl)butan-1-one Haloperidol for peak identification, European Pharmacopoeia (EP) Reference Standard CCG-39111 NCGC00015500-07 4763-EP2275420A1 Haloperidol, European Pharmacopoeia (EP) Reference Standard D0D1AL NCGC00015500-15 4763-EP2298731A1 Halosten DSSTox_GSID_34150 HMS1920D03 Duraperidol NCGC00023875-09 52-86-8 HMS3712G12 Serenace (TN) Fortunan NSC-615296 AB00052008_24 InChI=1/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 SMR000058303 GTPL86 Peluces Aldo KBio2_006477 Spectrum_000861 Poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] AN-41634 Keselan 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)- Tocris-0931 QTL1_000042 Bioperidolo Lopac-H-1512 4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone UNII-J6292F8L3D Brotopon MFCD00051423 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone Haloperidol (Haldol) C01814 NCGC00015500-02 4763-EP2269989A1 Haloperidol lactate NCGC00015500-10 4763-EP2292614A1 Haloperidol, United States Pharmacopeia (USP) Reference Standard DivK1c_000654 NCGC00015500-19 4763-EP2308867A2 4763-EP2311803A1 HMS2095G12 Einalon S (TN) NINDS_000654 A0H334 HY-14538 Serenelfi Galoperidol NSC615296 AC1L1G7K KBio1_000654 SPECTRUM1500325 Haldol (TN) Pernox Aloperidol KBio3_002869 SR-01000003076-2 Prestwick2_000115 Apo-Haloperidol Lealgin compositum Tox21_300475 Resin epoxy BPBio1_001231 LS-48311 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone W-105791 Halojust BSPBio_002096 MLS001146904 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one Haloperidol (JP17/USP/INN) CC-16450 NCGC00015500-05 4763-EP2272972A1 Haloperidol [USAN:USP:INN:BAN:JAN] CS-1971 NCGC00015500-13 4763-EP2295413A1 Halopidol Dozix NCGC00023875-04 [ Show all ]
Inchi Key	LNEPOXFFQSENCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
PubChem CID	3559
ChEMBL	CHEMBL54
IUPHAR	86
BindingDB	21398
DrugBank	DB00502
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID8996185	BindingDB
Ki	2.0 nM	PMID2885406	BindingDB
Ki	360.0 nM	PMID8822531	BindingDB
Ki	1088.0 nM	PMID2885406	BindingDB
Ki	1600.0 nM	PMID9430133	BindingDB
Ki	4783.0 nM	PMID2885406	BindingDB
Ki	5000.0 nM	PMID8935801	BindingDB
Ki	7050.0 nM	PMID2869639	BindingDB
Ki	7100.0 nM	PMID2138666	BindingDB

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