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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Mus musculus (Mouse)
Gene	Hcar2
Synonym	Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 HCA2 receptor G-protein coupled receptor HM74A G-protein coupled receptor HM74 G-protein coupled receptor 109A G-protein coupled receptor 109 G protein-coupled receptor 109A PUMAG [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
UniProt	Q9EP66
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4420
IUPHAR	312
DrugBank	N/A

Ligand

Name	MK-0354
Molecular formula	C7H8N6
IUPAC name	3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole
Molecular weight	176.183
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.2
Synonyms	1,4,5,6-Tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole 4U62D8JYIQ HY-13008 SCHEMBL1875705 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole Cyclopenta(C)pyrazole, 1,4,5,6-tetrahydro-3-(1H-tetrazol-5-yl)- MK 0354 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole BCP18112 NCGC00263122-01 1,4,5,6-Tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole(MK-0354) 5-{1H,4H,5H,6H-CYCLOPENTA[C]PYRAZOL-3-YL}-1H-1,2,3,4-TETRAZOLE CHEMBL456145 KB-78878 UNII-4U62D8JYIQ 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole 851776-28-8 D0A5MR 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[d]pyrazole BDBM50273099 GTPL5784 NCGC00263122-02 1,4,5,6-tetrahydro-3-(2H-tetrazol-5-yl)Cyclopentapyrazole CS-4589 LTQYSJKGRPGMPO-UHFFFAOYSA-N ZINC38312374 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopentapyrazole AKOS030526928 DA-02747 MolPort-009-683-033 [ Show all ]
Inchi Key	LTQYSJKGRPGMPO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H8N6/c1-2-4-5(3-1)8-9-6(4)7-10-12-13-11-7/h1-3H2,(H,8,9)(H,10,11,12,13)
PubChem CID	11159621
ChEMBL	CHEMBL456145
IUPHAR	5784
BindingDB	50273099
DrugBank	DB05939
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	400.0 nM	PMID18665582	BindingDB,ChEMBL
EC50	1080.0 nM	PMID18665582	BindingDB,ChEMBL
Efficacy	68.0 %	PMID18665582	ChEMBL
Efficacy	71.0 %	PMID18665582	ChEMBL
IC50	1200.0 nM	PMID19307116, PMID20615702	BindingDB,ChEMBL

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