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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Lysophosphatidic acid receptor 3
Species	Homo sapiens (Human)
Gene	LPAR3
Synonym	Lysophosphatidic acid receptor Edg-7 LPA3 receptor LPA-3 LPA receptor 3 endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7 Edg7 [ Show all ]
Disease	Fibrosis
Length	353
Amino acid sequence	MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
UniProt	Q9UBY5
Protein Data Bank	N/A
GPCR-HGmod model	Q9UBY5
3D structure model	This predicted structure model is from GPCR-EXP Q9UBY5.
BioLiP	N/A
Therapeutic Target Database	T95923
ChEMBL	CHEMBL3250
IUPHAR	274
DrugBank	N/A

Ligand

Name	Thiophosphoric acid dec-9-enyl ester
Molecular formula	C10H21O3PS
IUPAC name	dec-9-enoxy-dihydroxy-sulfanylidene-lambda5-phosphane
Molecular weight	252.309
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.2
Synonyms	D0F2SQ 849721-56-8 SCHEMBL192854 9-Decen-1-ol, dihydrogen phosphorothioate CHEMBL363935 BDBM50170855 [ Show all ]
Inchi Key	LWVBJTXDTCXEJG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H21O3PS/c1-2-3-4-5-6-7-8-9-10-13-14(11,12)15/h2H,1,3-10H2,(H2,11,12,15)
PubChem CID	11288209
ChEMBL	CHEMBL363935
IUPHAR	N/A
BindingDB	50170855
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	340.0 nM	PMID16033271	BindingDB,ChEMBL
Ki	128.0 nM	PMID16033271	BindingDB,ChEMBL

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