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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Homo sapiens (Human)
Gene	HTR2C
Synonym	Serotonin receptor 2C serotonin 1c receptor 5-HT1C 5-HT2C 5-HT-2C 5-HT2C receptor 5-HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-hydroxytryptamine receptor 1C HTR1C 5-HT-1C [ Show all ]
Disease	Pain Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia Unspecified Depression Drug abuse Generalized anxiety disorder; Major depressive disorder Major depressive disorder Metabolic disorders Psychotic disorders Mood disorder Neurological disease Obesity Obesity; Diabetes Migraine headaches Anxiety disorder Alcohol use disorders Aggressive non-hodgkin's lymphoma [ Show all ]
Length	458
Amino acid sequence	MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
UniProt	P28335
Protein Data Bank	6bqg, 6bqh
GPCR-HGmod model	P28335
3D structure model	This structure is from PDB ID 6bqg.
BioLiP	BL0404805, BL0404806
Therapeutic Target Database	T83813
ChEMBL	CHEMBL225
IUPHAR	8
DrugBank	BE0004957, BE0004881, BE0000533

Ligand

Name	imipramine
Molecular formula	C19H24N2
IUPAC name	3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Molecular weight	280.415
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.8
Synonyms	Pramine Imipraminum AB00053486_17 Psychoforin (Salt/Mix) Imizinum (Salt/Mix) Antideprin (TN) Spectrum2_000990 Janimine (hydrochloride) BRD-K38436528-003-05-5 Surplix (TN) KBioGR_000391 CCG-36485 Tofranil(TN) D06ZUK 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine W0042 Melipramin Dimipressin 3-(10,11-dihydro-5h-dibenz[b,f]azepin-5-yl)propyldimethylamine N-(gamma.-Dimethylaminopropyl)iminodibenzyl Dynaprin 5,e]azepine NCGC00015563-08 G-22355 (Salt/Mix) 5H-Dibenz(b, 10,11-dihydro-5-(3-(dimethylamino)propyl)- NINDS_000559 Imipramil (TN) 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-(9CI) 5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)propyl]-10,11-dihydro- Prestwick1_000072 Imizin AJ-08423 SCHEMBL34282 Intalpram BCGWQEUPMDMJNV-UHFFFAOYSA-N Spectrum5_000864 KBio1_000559 BSPBio_000283 Tofranil (free base) Lopac-I-7379 Censtin (3-{2-azatricyclo[9.4.0.0;{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)dimethylamine Tofraniln A DB00458 2,2'-(3-Dimethylaminopropylimino)dibenzyl MolPort-001-783-692 DSSTox_CID_23881 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE NCGC00015563-03 Eupramin 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine NCGC00015563-11 HSDB 3100 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)- NSC 169866 Imipramina [INN-Spanish] OGG85SX4E4 Imipramine (INN) AB00053486-15 Promiben Imizine (Salt/Mix) AN-41560 SPBio_001059 Irmin (TN) BIDD:GT0116 Surplix KBio2_006531 CAS-113-52-0 Tofranil (TN) CHEMBL11 1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine UNII-OGG85SX4E4 Deprinol (TN) 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine N-(3-Dimethylaminopropyl)-o-iminodibenzyl DTXSID1043881 5,6-Dihydro-N-[3-(dimethylamino)propyl]-11H-dibenz[b,e]azepine NCGC00015563-06 FT-0697093 50-49-7 NCGC00024253-04 Imavate (Salt/Mix) 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl- 5H-Dibenz[b, 10,11-dihydro-N,N-dimethyl- Prazepine Imipraminum [INN-Latin] AC1L1GIE PubChem21397 Impramine API0006755 Spectrum3_000466 Janimine (TN) BRD-K38436528-003-15-4 Timolet KBioSS_001395 CCRIS 9173 Tofranil, base D08070 113-52-0 (mono-hydrochloride) WLN: T C676 BN&T&J B3N1&1 Melipramin (TN) DivK1c_000559 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine NCGC00015563-01 Dynaprin (TN) 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine NCGC00015563-09 GTPL357 5H-Dibenz(b, 5-(3-(dimethylamino)propyl)-10,11-dihydro- Norchlorimipramine Imipramin 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl- Prestwick2_000072 Imizin (Salt/Mix) AK116463 SK-Pramine Iramil BDBM50010859 Spectrum_000915 KBio2_001395 BSPBio_002172 Tofranil (hydrochloride) Lopac0_000702 CHEBI:47499 Tox21_110174 Declomipramine 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine MRF-0000592 DSSTox_GSID_43881 NCGC00015563-04 Eupramin (Salt/Mix) 5-(3-Dimethylaminopropyl)-10,f)azepine NCGC00015563-13 IDI1_000559 5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-10,11-dihydro- NSC-169866 Imipramina [Italian] Oprea1_200908 Imipramine [INN:BAN] AB00053486_16 Psychoforin Imizinum Antideprin SPBio_002204 Janimine BPBio1_000313 Surplix (Salt/Mix) KBio3_001392 CAS-50-49-7 Tofranil base Clomipramine HCl EP Impurity B 10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine W-109253 MCULE-9471074673 Depsonil (TN) 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine;3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine N-(gamma-Dimethylaminopropyl)iminodibenzyl Dyna-zina 5,e)azepine NCGC00015563-07 G-22355 Nelipramin Imidobenzyle 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl- (9CI) 5H-Dibenz[b, 5-[3-(dimethylamino)propyl]-10,11-dihydro- Prestwick0_000072 Imiprin ACM50497 SBI-0050680.P004 InChI=1/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H AX8134492 Spectrum4_000016 KB-232392 BRN 0256892 Tofranil L000739 Censtim Tofranil-PM 2,2'-(3-Dimethylaminopropylimino)bibenzyl ZINC20245 Melipramine Dpid 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine NCGC00015563-02 EINECS 200-042-1 5-(3-(Dimethylamino)propyl)-10,f)azepine NCGC00015563-10 HMS2089G08 5H-Dibenz(b,5-[3-(dimethylamino)propyl]-10,11-dihydro-mixed with ethyl alcohol Norfranil Imipramina AB00053486 Prestwick3_000072 Imizine AKOS016010320 SK-Pramine (Salt/Mix) Irmin Berkomine STL416211 KBio2_003963 C07049 Tofranil (Salt/Mix) LS-60467 1-(3-Dimethylaminopropyl)-4,3,6,7-dibenzazepine Tox21_110174_1 Deprimin (TN) 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine # N-(.gamma.-Dimethylaminopropyl)iminodibenzyl DSSTox_RID_80080 5,6-Dihydro-N-(3-(dimethylamino)propyl)-11H-dibenz(b,e)azepine NCGC00015563-05 Eupramin (TN) 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine NCGC00024253-03 Imavate 5H-Dibenz(b,f)azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-mixed with ethyl alcohol NSC169866 [ Show all ]
Inchi Key	BCGWQEUPMDMJNV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
PubChem CID	3696
ChEMBL	CHEMBL11
IUPHAR	357
BindingDB	50010859
DrugBank	DB00458
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Ki	120.0 nM	PMID16712488	PDSP
Ki	150.0 nM	PMID7855217	BindingDB
Ki	160.0 nM	PMID15081025	BindingDB,ChEMBL

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