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GLASS

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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	5-OH-Dpat
Molecular formula	C16H25NO
IUPAC name	6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
Molecular weight	247.382
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	(-)-5-hydroxy-2-(dipropylamino)tetralin 5-hydroxy-N,N-dipropyl-2-aminotetralin AC1L58V4 SCHEMBL279021 6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol CHEMBL273273 5-hydroxy-2-(dipropylamino)tetralin 6-dipropylaminotetralin-1-ol GTPL128 (-)-6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol BDBM50020221 2-Dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol D00QHR 5-Hydroxy-2-N,N-dipropylaminotetralin 68593-96-4 L000957 1-Naphthalenol, 6-(dipropylamino)-5,6,7,8-tetrahydro- 5-Hydroxy-2-(di-n-propylamino)tetralin 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol (DP-5-ADTN) D0H3KU [ Show all ]
Inchi Key	MDBWEQVKJDMEMK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-8-9-15-13(12-14)6-5-7-16(15)18/h5-7,14,18H,3-4,8-12H2,1-2H3
PubChem CID	172267
ChEMBL	CHEMBL273273
IUPHAR	128
BindingDB	50020221
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.14 nM	PMID19427222	BindingDB,ChEMBL
EC50	1.23 nM	PMID20038106	BindingDB,ChEMBL
Emax	91.2 %	PMID20038106	ChEMBL
Emax	92.2 %	PMID19427222	ChEMBL
Ki	0.66 nM	PMID7636875	BindingDB,ChEMBL
Ki	1.36 nM	PMID20038106, PMID20146482	BindingDB,ChEMBL
Ki	4.4 nM	, Bioorg. Med. Chem. Lett., (1997) 7:21:2759	BindingDB,ChEMBL

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