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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	2-(4-chloro-2-methylphenoxy)-N-(2-morpholin-4-ylphenyl)acetamide
Molecular formula	C19H21ClN2O3
IUPAC name	2-(4-chloro-2-methylphenoxy)-N-(2-morpholin-4-ylphenyl)acetamide
Molecular weight	360.838
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.5
Synonyms	AN-465/41401560 Oprea1_777955 2-(4-chloro-2-methylphenoxy)-N-[2-(4-morpholinyl)phenyl]acetamide CHEMBL1480952 SR-01000256940-1 AC1LKEGW MLS000063060 Cambridge id 7269623 SMR000071963 2-(4-chloro-2-methylphenoxy)-N-[2-(morpholin-4-yl)phenyl]acetamide HMS2386C12 STK024479 AKOS000458397 MolPort-000-800-214 SR-01000256940 529501-79-9 MCULE-4790343064 ZINC679043 [ Show all ]
Inchi Key	ADCOWDURDSZLKK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21ClN2O3/c1-14-12-15(20)6-7-18(14)25-13-19(23)21-16-4-2-3-5-17(16)22-8-10-24-11-9-22/h2-7,12H,8-11,13H2,1H3,(H,21,23)
PubChem CID	1017018
ChEMBL	CHEMBL1480952
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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