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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 1
Species	Homo sapiens (Human)
Gene	TAAR1
Synonym	trace amine receptor 1 TAR1 TaR-1 TA1 receptor TRAR1
Disease	N/A
Length	339
Amino acid sequence	MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
UniProt	Q96RJ0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RJ0
3D structure model	This predicted structure model is from GPCR-EXP Q96RJ0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5857
IUPHAR	364
DrugBank	BE0001044

Ligand

Name	(R)-Mda
Molecular formula	C10H13NO2
IUPAC name	(2R)-1-(1,3-benzodioxol-5-yl)propan-2-amine
Molecular weight	179.219
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.6
Synonyms	CAS_3046161 Phenethylamine, alpha-methyl-3,4-(methylenedioxy)-, (R)- LS-103645 UNII-M3P34V176U (2R)-1-(1,3-benzodioxol-5-yl)propan-2-amine 1,3-Benzodioxole-5-ethanamine, alpha-methyl-, (R)- (9CI) NSC_3046161 (R)-alpha-Methyl-3,4-(methylenedioxy)phenethylamine AC1MIJOZ SCHEMBL9361151 1,3-Benzodioxole-5-ethanamine, alpha-methyl-, (alphaR)- M3P34V176U ZINC741 (R)-3,4-Methylenedioxyamphetamine 61614-60-6 PDSP2_001395 (R)-beta-3,4-(Methylenedioxy)amphetamine BDBM86239 CHEMBL1927025 Tenamfetamine, (-)- 1,3-Benzodioxole-5-ethanamine, alpha-methyl-, (R)- MDA,R(-) (R)-alpha-Methyl-1,3-benzodioxole-5-ethanamine [ Show all ]
Inchi Key	NGBBVGZWCFBOGO-SSDOTTSWSA-N
Inchi ID	InChI=1S/C10H13NO2/c1-7(11)4-8-2-3-9-10(5-8)13-6-12-9/h2-3,5,7H,4,6,11H2,1H3/t7-/m1/s1
PubChem CID	3046161
ChEMBL	CHEMBL1927025
IUPHAR	N/A
BindingDB	86239
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	11730.0 nM	PMID22037049	BindingDB,ChEMBL

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