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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Mus musculus (Mouse)
Gene	Ptgfr
Synonym	prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor PGF receptor PF2AR FP receptor Prostanoid FP receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	366
Amino acid sequence	MSMNSSKQPVSPAAGLIANTTCQTENRLSVFFSIIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFDQSNILCSIFGISMVFSGLCPLFLGSAMAIERCIGVTNPIFHSTKITSKHVKMILSGVCMFAVFVAVLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSFLGLLALGVSFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMIIQLLAIMCVSCVCWSPFLVTMANIAINGNNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELSSIKNSLKVAAISESPAAEKESQQASSEAGL
UniProt	P43117
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5000
IUPHAR	344
DrugBank	N/A

Ligand

Name	dinoprost
Molecular formula	C20H34O5
IUPAC name	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
Molecular weight	354.487
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	2.7
Synonyms	l-PGF2-alpha (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid NCGC00160385-05 5-HEPTENOIC ACID, 7-(3,5-DIHYDROXY-2-(3-HYDROXY-1-OCTENYL)CYCLOPENTYL)-, dl- PGF2-alpha 9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9alpha,11alpha,13E,15S)- amoglandin prostaglandin F2alpha C00639 PXGPLTODNUVGFL-YNNPMVKQSA-N CHEMBL815 U 14583 DSSTox_CID_2946 HMS1791K16 (+-)-PGF2alpha (5Z,9alpha,11alpha,13E,15S)-9,11,15-Trihydroxyprosta-3,13-dien-1-oic acid LS-125835 13535-33-6 panacelan 551-11-1 PGF2a 9alpha,11alpha-PGF2 Prostaglandin F2 alpha BDBM50035622 Prostarmon F CCG-208257 SR-01000721847-2 cyclosin UNII-B7IN85G1HY Dinoprosta DTXSID9022946 HMS3402K16 (5z,9alpha,11alpha,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid NCGC00160385-02 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, (+-)- PGF2 7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic acid Prosta-10,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9.alpha.,11.alpha.,13E,15S) AC1NQWY5 Prostaglandin F2.alpha. BRN 4153898 Prostin F2alpha CHEBI:15553 SR-01000946457-1 Dinoprostum [INN-Latin] GTPL1884 (+)-Prostaglandin F2alpha HY-12956 l-Prostaglandin F2-alpha (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid NCGC00160385-06 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, l- PGF2-alpha racemic mixt. 99437-94-2 Prostaglandin F(sub 2a) AN-796 Prostaglandin F2alpha, dl- C20H34O5 SCHEMBL24292 CP0104 U-14,583 Dinoprost (JP17/USAN/INN) DSSTox_GSID_22946 HMS1989K16 (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid MolPort-005-940-967 PDSP2_000079 62P015 PGF2alpha 9alpha,11beta-PGF2 Prostaglandin F2-alpha BML1-F08 Prostin F 2 alpha CCRIS 4253 SR-01000721847-4 D00081 Y0222 Dinoprosta [INN-Spanish] Enzaprost ( )-Prostaglandin F2alpha HMS3648N11 IDI1_033964 (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid NCGC00160385-04 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, (1R-(1alpha(Z),2beta(S*,E),3alpha,5alpha))- PGF2 alpha 9,11,15-Trihydroxy-(5Z,9a,11a,13E,15S)-prosta-5,13-dien-1-oic acid Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9-alpha,11-alpha,13E,15S)-(+-)- (9CI) AKOS030526160 Prostaglandin F2a BSPBio_001494 Protamodin Tox21_111777 DB12789 dl-Prostaglandin F2-alpha HMS1361K16 (+-)-PGF2-alpha LMFA03010002 (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(E)-(3S)-3-hydroxy-1-octenyl}-cyclopentyl]-5-heptenoic acid P1885 PGF2.alpha. 9a,11a-PGF2 Prostaglandin F2 B7IN85G1HY Prostaglandin F2\|A CAS-551-11-1 SR-01000721847 CS-4232 U-14583 Dinoprost [USAN:INN:BAN:JAN] DSSTox_RID_76800 HMS2089F11 (5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid (5Z,9alpha,11alpha,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoate NCGC00160385-01 23518-25-4 PGF-2alpha 7-(3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoic acid Prosmon (TN) 9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid Prostaglandin F2-alpha, racemic mixt. BRN 2225571 Prostin F2-alpha Cerviprost SR-01000946457 D00HTY ZINC3830709 Dinoprostum Enzaprost F (+)-Prostaglandin F2a HSDB 3315 [ Show all ]
Inchi Key	PXGPLTODNUVGFL-YNNPMVKQSA-N
Inchi ID	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
PubChem CID	5280363
ChEMBL	CHEMBL815
IUPHAR	1884
BindingDB	50035622
DrugBank	DB12789
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	92.0 %	PMID19101156	ChEMBL
EC50	12.59 nM	PMID23317571	ChEMBL
EC50	24.5 nM	PMID19101156	BindingDB,ChEMBL
Intrinsic activity	1.0 -	PMID23317571	ChEMBL
Ki	3.16228 nM	PMID9313928	IUPHAR

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