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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Beta-3 adrenergic receptor
Species	Canis lupus familiaris (Dog)
Gene	ADRB3
Synonym	Beta-3 adrenoceptor Beta-3 adrenoreceptor
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MAPWPHGNGSVASWPAAPTPTPDAANTSGLPGAPWAVALAGALLALEVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVGADAEAQRCHSNPHCCAFASNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQLRLLRRELGRFPPAESPPAASRSRSPGPARRCASPAAVPSDRLRPARLLPLREHRALRTLGLIVGTFTLCWLPFFVANVMRALGGPSLVPSPALLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCRREEHRAAASPPGDPSAAPAALTSPAESSRCQALDGASWGIS
UniProt	O02662
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4400
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL271945
Molecular formula	C26H29NO4
IUPAC name	4-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-2-propan-2-yloxybenzoic acid
Molecular weight	419.521
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	2.2
Synonyms	4''-[2-((R)-2-Hydroxy-2-phenyl-ethylamino)-ethyl]-3-isopropoxy-biphenyl-4-carboxylic acid 4'-[2-[[(betaR)-beta-Hydroxyphenethyl]amino]ethyl]-3-isopropoxy-4-biphenylcarboxylic acid BDBM50236185 (R)-4''-(2-(2-hydroxy-2-phenylethylamino)ethyl)-3-isopropoxybiphenyl-4-carboxylic acid 4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-isopropoxy-4-biphenylcarboxylic acid
Inchi Key	PZOXHDZLMHAWOO-DEOSSOPVSA-N
Inchi ID	InChI=1S/C26H29NO4/c1-18(2)31-25-16-22(12-13-23(25)26(29)30)20-10-8-19(9-11-20)14-15-27-17-24(28)21-6-4-3-5-7-21/h3-13,16,18,24,27-28H,14-15,17H2,1-2H3,(H,29,30)/t24-/m0/s1
PubChem CID	24822974
ChEMBL	CHEMBL271945
IUPHAR	N/A
BindingDB	50236185
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.9 nM	PMID18307290, PMID19366244, PMID18553954	BindingDB,ChEMBL
Intrinsic activity	0.97 -	PMID18553954	ChEMBL
Ratio	0.97 -	PMID18307290	ChEMBL

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