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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Homo sapiens (Human)
Gene	CHRM2
Synonym	cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 cholinergic receptor, muscarinic 2, cardiac cholinergic receptor, muscarinic 2 [ Show all ]
Disease	Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer Stabilize muscle contractions Unspecified Cardiovascular disorder Asthma Alzheimer disease [ Show all ]
Length	466
Amino acid sequence	MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P08172
Protein Data Bank	5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8
GPCR-HGmod model	P08172
3D structure model	This structure is from PDB ID 5zkc.
BioLiP	BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338
Therapeutic Target Database	T46185
ChEMBL	CHEMBL211
IUPHAR	14
DrugBank	BE0000560

Ligand

Name	pilocarpine
Molecular formula	C11H16N2O2
IUPAC name	(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
Molecular weight	208.261
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	1.1
Synonyms	KBio3_001691 (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one Mi-Pilo 01MI4Q9DI3 NCGC00023339-09 NINDS_000358 AI3-50523 Ocusert Pilo-40 BDBM50008072 Pilocarpine monohydrochloride C07474 Pilokarpin Piloptic-6 EINECS 202-128-4 Salagen (TN) Isopto carpine Spectrum2_001284 Spectrum3_000546 Timpilo (TN) Lopac0_000950 (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one Miocarpine (TN) 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)- NCGC00023339-12 AB00053525-27 Ocusert AKOS016010311 Pilocarpin BPBio1_000548 Pilocarpine [USAN:BAN:JAN] CHEBI:8207 Piloptic-1 DivK1c_000358 Prestwick1_000449 HMS2089K17 Scheinpharm (TN) KB-207616 Spectrum_001107 Tox21_110887_1 KBio2_004155 (+)-Pilocarpine LS-7661 (3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone NCGC00023339-07 3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one NCGC00023339-16 AC1L1LEF Ocusert pilo-20 AN-42585 Pilocarpine (TN) BSPBio_000498 Pilocarpine-d3 HCl (deuterated) D00525 Piloptic-3 DSSTox_RID_75984 QCHFTSOMWOSFHM-WPRPVWTQSA-N Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone SPBio_001287 ST069319 KBioGR_000956 (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one Minims Pilocarpine 092P137 NCGC00023339-10 91484-73-0 NSC5746 AK116461 P.V. Carpine Liquifilm beta-Pilocarpine hydrochloride Pilocarpine Mononitrate, (3S-cis)-Isomer CAS-92-13-7 Pilokarpol DB01085 Pilostat Epicar SBB012409 Isopto carpine (TN) Spectrum4_000478 Tocris-0694 Lopac0_000960 (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]tetrahydrofuran-2-one NCGC00023339-03 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)- NCGC00023339-13 AB00053525_28 Ocusert P 20 Almocarpine BRD-K85090592-008-05-2 Pilocarpine [USP:BAN:JAN] Piloptic-1/2 DSSTox_CID_1162 Prestwick2_000449 HSDB 3163 SCHEMBL15146 KBio1_000358 Spersacarpine UNII-01MI4Q9DI3 KBio2_006723 (3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one MCULE-2634151840 (3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone NCGC00023339-08 NCI60_004403 Adsorbocarpine Ocusert pilo-20 (TN) AX8148055 Pilocarpine chloride BSPBio_002191 Pilocarpol D06HLY Piloptic-4 DTXSID1021162 Salagen isopilocarpine SPBio_002437 Syncarpine KBioSS_001587 (3S,4R)-3-ethyl-4-[(1-methylimidazol-5-yl)methyl]-3,4,5-trihydrofuran-2-one Miocarpine 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)- NCGC00023339-11 92-13-7 Ocu-Carpine Akarpine Pilagan BIDD:GT0217 Pilocarpine nitrate salt CCG-205031 Pilopine HS (TN) Diocarpine (TN) Prestwick0_000449 GTPL305 SBI-0050924.P004 Isoptocarpine Spectrum5_001379 Tox21_110887 KBio2_001587 LS-187208 (3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone NCGC00023339-06 3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one NCGC00023339-14 AB00053525_29 Ocusert pilo Amistura P Pilocarpine (JAN/USP) BRD-K85090592-008-15-1 Pilocarpine, Monohydrochloride, (3S-cis)-Isomer CHEMBL550 Piloptic-2 DSSTox_GSID_21162 Prestwick3_000449 IDI1_000358 SDCCGMLS-0003164.P005 SR-01000075339-11 ZINC75008 [ Show all ]
Inchi Key	QCHFTSOMWOSFHM-WPRPVWTQSA-N
Inchi ID	InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1
PubChem CID	5910
ChEMBL	CHEMBL550
IUPHAR	305
BindingDB	50008072
DrugBank	DB01085
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
EC50	63000.0 nM	PMID9873644	BindingDB,ChEMBL
Efficacy	73.3 %	PMID25765911	ChEMBL
Ki	12022.6 nM	PMID18182302	ChEMBL
Ki	12589.3 nM	PMID9224827	IUPHAR
Max cAMP	59.0 %	PMID9873644	ChEMBL
Ratio	2.0 -	Bioorg. Med. Chem. Lett., (1991) 1:3:147	ChEMBL

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