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GPCR

NameG-protein coupled receptor 4
SpeciesHomo sapiens (Human)
GeneGPR4
SynonymG-protein coupled receptor 19
GPR19
GPR4
DiseaseN/A
Length362
Amino acid sequenceMGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ
UniProtP46093
Protein Data BankN/A
GPCR-HGmod modelP46093
3D structure modelThis predicted structure model is from GPCR-EXP P46093.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3638324
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3670937
Molecular formulaC25H33N5O
IUPAC name[(2S)-4-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-2-yl]methanol
Molecular weight419.573
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP3.1
SynonymsSCHEMBL12802763
US8748435, 8
BDBM123483
SCHEMBL12802758
Inchi KeyBNRHMRYRONRUHO-BDNZGDGKSA-N
Inchi IDInChI=1S/C25H33N5O/c1-4-24-23(25-27-18(2)14-19(3)30(25)28-24)15-21-9-7-20(8-10-21)6-5-12-29-13-11-26-22(16-29)17-31/h5-10,14,22,26,31H,4,11-13,15-17H2,1-3H3/b6-5+/t22-/m0/s1
PubChem CID68379138
ChEMBLCHEMBL3670937
IUPHARN/A
BindingDB123483
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5028.0 nM, NoneBindingDB,ChEMBL

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