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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	Opc-4392
Molecular formula	C24H29N3O2
IUPAC name	7-[3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propoxy]-1H-quinolin-2-one
Molecular weight	391.515
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.0
Synonyms	7-(3-(4-(2,3-Dimethylphenyl)piperazinyl)propoxy)-2(1H)-quinolone CAS_163839 111073-34-8 D09ULA SCHEMBL2424904 2(1H)-Quinolinone,7-[3-[4-(2,3-dimethylphenyl)-1-piperazinyl]propoxy]- ACMC-20dcav NSC_163839 7-[3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propoxy]-1H-quinolin-2-one CHEMBL55171 PDSP1_000687 2(1H)-Quinolinone, 7-(3-(4-(2,3-dimethylphenyl)-1-piperazinyl)propoxy)- AC1L4TPA GTPL268 ZINC5116306 BDBM82065 Opc 4392 7-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propoxy}quinolin-2(1h)-one CTK4A7166 PDSP2_000677 2(1H)-Quinolinone, 7-[3-[4-(2,3-dimethylphenyl)-1-piperazinyl]propoxy]- AC1Q6O88 L001306 [ Show all ]
Inchi Key	RRLWEQBPSAFVAS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H29N3O2/c1-18-5-3-6-23(19(18)2)27-14-12-26(13-15-27)11-4-16-29-21-9-7-20-8-10-24(28)25-22(20)17-21/h3,5-10,17H,4,11-16H2,1-2H3,(H,25,28)
PubChem CID	163839
ChEMBL	N/A
IUPHAR	268
BindingDB	82065
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	630.957 nM	PMID10327430	IUPHAR
Ki	680.0 nM	PMID10327430	BindingDB

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