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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R GnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30969
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3066
IUPHAR	256
DrugBank	N/A

Ligand

Name	CHEMBL2370317
Molecular formula	C30H44N8O5
IUPAC name	(2S)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methylpentanamide
Molecular weight	596.733
Hydrogen bond acceptor	6
Hydrogen bond donor	7
XlogP	1.1
Synonyms	N/A
Inchi Key	BRRKSUIUCJAWRV-MGKKLRQFSA-N
Inchi ID	InChI=1S/C30H44N8O5/c1-17(2)14-24(28(42)37-23(10-7-13-34-30(32)33)27(41)35-18(3)26(31)40)38-29(43)25(36-19(4)39)16-20-11-12-21-8-5-6-9-22(21)15-20/h5-6,8-9,11-12,15,17-18,23-25H,7,10,13-14,16H2,1-4H3,(H2,31,40)(H,35,41)(H,36,39)(H,37,42)(H,38,43)(H4,32,33,34)/t18-,23-,24-,25-/m0/s1
PubChem CID	73348487
ChEMBL	CHEMBL2370317
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Activity	3.5 -	PMID7636852	ChEMBL
Activity	49.0 -	PMID7636852	ChEMBL
Activity	87.0 -	PMID7636852	ChEMBL
Activity	116.0 -	PMID7636852	ChEMBL
Activity	136.0 -	PMID7636852	ChEMBL
Activity	145.0 -	PMID7636852	ChEMBL

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