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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 2
Species	Rattus norvegicus (Rat)
Gene	F2rl1
Synonym	coagulation factor II (thrombin) receptor-like 1 coagulation factor II receptor-like 1 GPR11 PAR-2 PAR2 Protease-activated receptor-2 Thrombin receptor-like 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	397
Amino acid sequence	MRSLSLAWLLGGITLLAASASCNRTVNAPGPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSASVLTGKLTTVFLPVIYIIVFVIGLPSNGMALWVFFFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNDWTYGDALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKRANIAVGVSLAIWLLIFLVTIPLYVMRQTIYIPALNITTCHDVLPEEVLVGDMFSYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAMDEHSEKKRRRAIRLIITVLSMYFICFAPSNVLLVVHYFLIKSQRQSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDQARNALLCRSVRTVKRMQISLTSNKFSRKSSSYSSSSTSVKTSY
UniProt	Q63645
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2429706
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SLIGRL-NH2
Molecular formula	C29H56N10O7
IUPAC name	(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-N-[2-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-methylpentanamide
Molecular weight	656.83
Hydrogen bond acceptor	9
Hydrogen bond donor	10
XlogP	-1.3
Synonyms	PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt SL-NH2 171436-38-7 H-SER-LEU-ILE-GLY-ARG-LEU-NH2 Protease-Activated Receptor-2 Activating Peptide ZINC26468553 BDBM85517 MolPort-023-276-115 Ser-Leu-Ile-Gly-Arg-Leu-NH(2) CHEMBL238078 PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt, >=97% (HPLC) SLIGRL-NH HY-P1308 Ser-Leu-Ile-Gly-Arg-Leu-amide CAS_171436-38-7 PAR-2 (1-6) amide (mouse, rat) Ser-Leu-Ile-Gly-Arg-Leu-NH2 CS-0029354 PAR-2-AP AKOS024456619 LS-191961 Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt [ Show all ]
Inchi Key	SGPMJRPYYIJZPC-JYAZKYGWSA-N
Inchi ID	InChI=1S/C29H56N10O7/c1-7-17(6)23(39-27(45)21(12-16(4)5)38-25(43)18(30)14-40)28(46)35-13-22(41)36-19(9-8-10-34-29(32)33)26(44)37-20(24(31)42)11-15(2)3/h15-21,23,40H,7-14,30H2,1-6H3,(H2,31,42)(H,35,46)(H,36,41)(H,37,44)(H,38,43)(H,39,45)(H4,32,33,34)/t17-,18-,19-,20-,21-,23-/m0/s1
PubChem CID	9831050
ChEMBL	CHEMBL238078
IUPHAR	N/A
BindingDB	85517
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	260.0 nM	PMID10411588	BindingDB

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