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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(4) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd4
Synonym	D(2C) dopamine receptor D4 receptor D4R Dopamine D4 receptor dopamine receptor 4
Disease	N/A for non-human GPCRs
Length	387
Amino acid sequence	MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProt	P30729
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3361
IUPHAR	217
DrugBank	N/A

Ligand

Name	Dinapsoline,(+/-)-4-Methyl
Molecular formula	C17H17NO2
IUPAC name	(1S)-12-methyl-15-azatetracyclo[7.7.1.02,7.013,17]heptadeca-2(7),3,5,9(17),10,12-hexaene-5,6-diol
Molecular weight	267.328
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	2.4
Synonyms	BDBM86184
Inchi Key	SOZRZRILJRQXRJ-AWEZNQCLSA-N
Inchi ID	InChI=1S/C17H17NO2/c1-9-2-3-10-6-12-11(4-5-15(19)17(12)20)14-8-18-7-13(9)16(10)14/h2-5,14,18-20H,6-8H2,1H3/t14-/m0/s1
PubChem CID	57340492
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86184
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	83.0 nM	PMID12628671	BindingDB

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