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GPCR

NameN-arachidonyl glycine receptor
SpeciesHomo sapiens (Human)
GeneGPR18
SynonymGPCRW
G-protein coupled receptor 18
N-arachidonoyol glycine receptor
NAGly receptor
GPR18
DiseaseN/A
Length331
Amino acid sequenceMITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProtQ14330
Protein Data BankN/A
GPCR-HGmod modelQ14330
3D structure modelThis predicted structure model is from GPCR-EXP Q14330.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2384898
IUPHAR89
DrugBankBE0002304

Ligand

NameCHEMBL3221197
Molecular formulaC21H20N2O2S
IUPAC name(2Z)-2-[(3-phenylmethoxyphenyl)methylidene]-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3-one
Molecular weight364.463
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.4
Synonyms2-[3-(Benzyloxy)benzylidene]-2,3,5,6,7,8-hexahydroimidazo[2,1-b][1,3]thiazepine-3-one
Inchi KeyTYPYKTGWUCNEDE-RGEXLXHISA-N
Inchi IDInChI=1S/C21H20N2O2S/c24-20-19(22-21-23(20)11-4-5-12-26-21)14-17-9-6-10-18(13-17)25-15-16-7-2-1-3-8-16/h1-3,6-10,13-14H,4-5,11-12,15H2/b19-14-
PubChem CID90667660
ChEMBLCHEMBL3221197
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity7.0 %MedChemComm, (2014) 5:5:632ChEMBL
IC5010000.0 nMMedChemComm, (2014) 5:5:632ChEMBL
Inhibition49.0 %MedChemComm, (2014) 5:5:632ChEMBL

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