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GPCR

Name	Adenosine receptor A1
Species	Homo sapiens (Human)
Gene	ADORA1
Synonym	RDC7 A1 receptor A1-AR A1R adenosine receptor A1
Disease	Cardiac arrhythmias Hypertension Cardiac disease Cognitive disorders Diabetes Fatigue; Orthostatic hypotension Glaucoma Heart failure Autoimmune diabetes Atrial fibrillation; Cardiac arrhythmias Atrial fibrillation Sepsis Renal failure Parkinson's disease Neuropathic pain Acute and chronic heart failure Multiple scierosis Hypertriglyceridemia Allergy Asthma Hyperlipidaemia [ Show all ]
Length	326
Amino acid sequence	MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
UniProt	P30542
Protein Data Bank	6d9h, 5n2s
GPCR-HGmod model	P30542
3D structure model	This structure is from PDB ID 6d9h.
BioLiP	BL0385576, BL0417675
Therapeutic Target Database	T88714, T92072
ChEMBL	CHEMBL226
IUPHAR	18
DrugBank	BE0000013

Ligand

Name	adenosine 5'-monophosphate
Molecular formula	C10H14N5O7P
IUPAC name	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Molecular weight	347.224
Hydrogen bond acceptor	11
Hydrogen bond donor	5
XlogP	-3.5
Synonyms	005A750 adenosine-5'P 1z6s Adenosine5'-monophosphate 5'-adenosine monophosphate Adenylic acid (VAN) 5'-O-phosphonatoadenosine AMP (VAN) 67583-85-1 bmse000005 9H-purin-6-amine, 9-(5-O-phosphono-beta-D-ribofuranosyl)- CAS-61-19-8 AC1Q1ID5 DB-022416 Adenosine 5'-Monophosphate, free acid Epitope ID:137353 Adenosine 5'-phosphorate FT-0619943 Adenosine phosphate [USAN:INN:BAN] Muskeladenylsaeure NSC-20264 Polyadenylic acids SC-17764 UNII-415SHH325A {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid FT-0696931 LS-15192 Adenosine-5-monophosphorate 34051-12-2 Adenovite 5'-Adenylic acid, 5'-thio- AK-54726 5'adenylic acid AN-23642 7A8E6D15-9136-44C1-88C9-E1A224638E56 BPBio1_000497 a-5mp CHEMBL752 Adenosine 5 inverted exclamation marka-monophosphate CAgarose DSSTox_GSID_22560 Adenosine 5'-monophosphate-Agarose, lyophilized powder Formycin 5'-phosphate Adenosine monophosphate Adenosine-5'-Monophosphate, Free acid MolPort-004-946-768 Myoston Phosphaden Prestwick2_000356 SPBio_002372 ZINC3860156 HY-A0181 ADENOSINE-5'-PHOSPHATE 1pyg adenosine-monophosphate 47286-65-7 adenylate 5'-AMP AMP 55036-25-4 ASMP 8gpb C00020 AB0010740 D02769 EBD2205244 Adenosine 5'-monophosphoric acid Fosfato de adenosina Adenosine phosphate (USAN/INN) ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate Muscle adenylic acid NCGC00163319-03 Phosphentaside RTR-030672 TR-030672 [(2R,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate;hydrate KSC352Q5L 13270-66-1 Adenosine-5-monophosphate dianion 24937-83-5 Adenosini phosphas 5'-adenylate Ado5'P 5'-O-phosphonoadenosine AMP dianion 697214-87-2 bmse000873 A 5MP CHEBI:16027 Adenine polynucleotides DB00131 Adenosine 5'-monophosphate, 99% Ergadenylic acid Adenosine 5'-phosphoric acid Adenosine, mono(dihydrogen phosphate) (ester) Lycedan My-B-Den PAdo Prestwick0_000356 SCHEMBL18287224 Vitamin B8 GTPL2455 Adenosine-5'-monophosphorate 18422-05-4 Adenosine-5-monophosphoric acid 4-26-00-03615 (Beilstein Handbook Reference) Adenyl 5'-Adenylic acid, 8-amino- AKOS015833068 5-adenylic acid ANW-33718 7gpb BRN 0054612 A0158 CS-0017523 Adenosine 5' monophosphate DSSTox_RID_76630 Adenosine 5'-monophosphate-Agarose, lyophilized powder, Contains lactose stabilizers that must be removed prior to use. Formycin 5'-phosphate hydrate Adenosine Monophosphate (Amp) Monophosphadenine NCGC00163319-01 Phosphate d'adenosine Prestwick3_000356 Tox21_112046 [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate J-700145 adenosine-5'-phosphoric acid 1ua4 adenosine-phosphate 47287-97-8 adenylic acid 5'-Deoxy-5'-thioadenosine 5'-monophosphate AMP (nucleotide) 61-19-8 BDBM18137 9H-Purin-6-amine, 9-(5-O-phosphono-.beta.-D-ribofuranosyl)- Cardiomone AC1L1LRL D06ACW Adenosine 5'-monophosphate monohydrate EINECS 200-500-0 adenosine 5'-phosphate Fosfato de adenosina [INN-Spanish] Adenosine phosphate [USAN:BAN:INN] (S)-1-C-(7-Amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)-1,4-anhydro-D-ribitol, 5-(dihydrogen phosphate) Muskeladenosin-phosphorsaeure NSC 20264 POLY A SBB001403 UDMBCSSLTHHNCD-KQYNXXCUSA-N [3h]adenosine 5'-monophosphate LS-129209 162756-82-3 Adenosine-5-monophosphate(2-) 2gsu Adenosini phosphas [INN-Latin] 5'-adenylic acid AJ-45954 5'-Thio-5'-adenylic acid AMP; 7-Amino-3-beta-D-ribofuranosyl-1H-pyrazolo(4,3-d)pyrimidine 5'-(dihydrogen phosphate) hydrate bmse000992 A-5'-P Adenosine 5 -monophosphate DSSTox_CID_2560 Adenosine 5'-monophosphate, free acid Formycin 5'-monophosphate hydrate Adenosine 5-Monophosphate Adenosine-5'-monophosphate MFCD00149360 My-beta-Den Phosaden Prestwick1_000356 SCHEMBL5588 W-105182 HSDB 3281 Adenosine-5'-monophosphoric acid 1H-Pyrazolo(4,3-d)pyrimidine, 7-amino-3-beta-D-ribofuranosyl-, 5'-(dihydrogen phosphate)-, hydrate Adenosine-5-phosphate 415SHH325A Adenyl (TN) 5'-Adenylic acid, homopolymer AKOS015888563 53624-78-5 AS-11783 8-Aminoadenosine 5'-monophosphate BSPBio_000451 A5MP CTK2F2855 Adenosine 5'-(dihydrogen phosphate) DTXSID5022560 Adenosine 5'-monophosphate-Agarose, saline suspension Formycin A 5'-monophosphate hydrate adenosine phosphate Muscle adenylate NCGC00163319-02 Phosphate d'adenosine [INN-French] PubChem14179 Tox21_112046_1 [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate KB-47163 [ Show all ]
Inchi Key	UDMBCSSLTHHNCD-KQYNXXCUSA-N
Inchi ID	InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
PubChem CID	6083
ChEMBL	CHEMBL752
IUPHAR	N/A
BindingDB	18137
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	500.0 nM	PMID22738238	BindingDB,ChEMBL

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