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GPCR

Name5-hydroxytryptamine receptor 2C
SpeciesRattus norvegicus (Rat)
GeneHtr2c
Synonym5-HT-1C
serotonin 1c receptor
HTR1C
5-hydroxytryptamine receptor 1C
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProtP08909
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL324
IUPHAR8
DrugBankBE0004882

Ligand

Name1-(3-Chlorophenyl)piperazine
Molecular formulaC10H13ClN2
IUPAC name1-(3-chlorophenyl)piperazine
Molecular weight196.678
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP1.7
SynonymsNCGC00015247-03
NSC-49307
6640-24-0
R1689
AKOS000101295
[ Show all ]
Inchi KeyVHFVKMTVMIZMIK-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2
PubChem CID1355
ChEMBLCHEMBL478
IUPHAR142
BindingDB50001915
DrugBankDB12110

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki19.95 nMPMID11298663BindingDB
Ki20.0 nMPMID9928251, PMID10611640BindingDB
Ki59.0 nMPMID11104741BindingDB
Ki63.0957 nMPMID11104741IUPHAR
Ki114.81 nMPMID9225287BindingDB
Ki125.89 nMPMID7582481BindingDB
Ki300.0 nMPMID9928251, PMID10611640BindingDB

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