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GLASS

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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL160372
Molecular formula	C15H11ClN2
IUPAC name	4-[5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine
Molecular weight	254.717
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.6
Synonyms	4-[5-(4-Chloro-phenyl)-1H-pyrrol-2-yl]-pyridine BDBM50075790
Inchi Key	XPWZPRGVSSXETH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H11ClN2/c16-13-3-1-11(2-4-13)14-5-6-15(18-14)12-7-9-17-10-8-12/h1-10,18H
PubChem CID	44372397
ChEMBL	CHEMBL160372
IUPHAR	N/A
BindingDB	50075790
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<3000.0 nM	PMID10201821	BindingDB,ChEMBL
IC50	140.0 nM	PMID10201821	BindingDB,ChEMBL

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