Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Canis lupus familiaris (Dog)
Gene	HTR2C
Synonym	5-HT-2C 5-HT2C 5-HTR2C Serotonin receptor 2C
Disease	N/A for non-human GPCRs
Length	458
Amino acid sequence	MVNLRKAVHSFLVHLIGLLVWQCDISVSPVAALVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIILTIGGNILVIMAVSLEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPVEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIHVLRRQALMLLHGHVEEPPRINLDFLKCCRRNGTEEENSANPNQDSNPRRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLVMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKPEKKPPVRQMPRVAATALSGRELNVNIYRHTNEPVLKKANDKEPGIEMQVENLELPVNPSSVVSERISSV
UniProt	Q60F97
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1770041
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Lorcaserin
Molecular formula	C11H14ClN
IUPAC name	(5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
Molecular weight	195.69
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.7
Synonyms	AN-6779 BDBM50161646 CTK8B8482 FCH873876 LS-193332 TX-017673 (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine 616202-92-7 APD356 CAS-616202-92-7 DB04871 HSDB 8128 SB16626 XTTZERNUQAFMOF-QMMMGPOBSA-N 10-chloro-2-methyl-4-azabicyclo[5.4.0]undeca-8,10,12-triene AB52744 AKOS006326204 AX8136671 CHEMBL360328 DSSTox_RID_82856 Lorcaserin [INN] Tox21_113018 (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine ANW-60436 Belvig D01JMC FT-0670852 NCGC00182550-01 UNII-637E494O0Z (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine 637E494O0Z API0005054 CHEBI:65353 DSSTox_CID_28585 HY-11093 SCHEMBL169382 ZINC6733300 1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-, (1R)- AC-553 AM81248 BC224451 CS-1232 DTXSID3048659 Lorqess Tox21_113018_1 (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine APD 356 Belviq GTPL2941 NCGC00182550-02 W-5409 (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine AB0148401 AR-10A DSSTox_GSID_48659 TL80074203 202L927 AJ-56780 [ Show all ]
Inchi Key	XTTZERNUQAFMOF-QMMMGPOBSA-N
Inchi ID	InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
PubChem CID	11658860
ChEMBL	CHEMBL360328
IUPHAR	2941
BindingDB	50161646
DrugBank	DB04871
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	82.0 %	PMID21195614	ChEMBL
EC50	16.2 nM	PMID21195614	BindingDB,ChEMBL

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218