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GPCR

Name	Delta-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprd1
Synonym	opioid receptor OP1 DOR-1 DOR DOPr DOP delta receptor D-OR-1 Opioid receptor A [ Show all ]
Disease	N/A for non-human GPCRs
Length	372
Amino acid sequence	MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
UniProt	P33533
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL269
IUPHAR	317
DrugBank	N/A

Ligand

Name	MET-enkephalin
Molecular formula	C27H35N5O7S
IUPAC name	(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
Molecular weight	573.665
Hydrogen bond acceptor	9
Hydrogen bond donor	7
XlogP	-2.1
Synonyms	NCGC00163683-01 YFGBQHOOROIVKG-FKBYEOEOSA-N (2S,5S,14S)-14-Amino-5-benzyl-15-(4-hydroxyphenyl)-2-(2-(methylthio)ethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid 2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid AK545848 CHEMBL13786 ENKEPHALIN, METHIONINE met-enkefalin Porcine beta-endorphin 1-5 [Met5]-ENKEPHALIN ([Met]-enkephalin)2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid([Met]-enkephalin 58569-55-4 C-54716 D0Y9EK H-Tyr-Gly-Gly-Phe-Met-OH METENKEFALIN MolPort-003-938-143 Tyr-Gly-Gly-Phe-Met-OH [Met]enkephalin (2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-4-methylsulfanyl-butanoic acid 2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-1-oxo-3-phenyl-propylamino]-4-methylsulfanyl-butyric acid AC1L9EIT CHEBI:6618 EINECS 261-335-8 Lupex NSC 374896 ZINC4102171 (Met5)-enkephalin AKOS030525639 CS-5426 FT-0770482 Metenkefalin [INN] SCHEMBL632433 [Met5]Enkephalin acetate salt hydrate 1-5-Adrenorphin (human) 82362-17-2 C11684 DB12668 HY-P0073 N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-methionine UNII-9JEZ9OD3AS (2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid 2-[1-[1-amino-2-(4-hydroxyphenyl)-(1S)-ethylcarboxamidomethylcarboxamidomethylcarboxamido]-2-phenyl-(1S)-ethylcarboxamido]-4-methylsulfanyl-(2S)-butanoic acid Adrenorphin (human), 6-de-L-arginine-7-de-L-arginine-8-de-L-valinamide- Enkephalin M Met-Enk Opioid growth factor [5-Methionine]Enkephalin (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid 569T554 BDBM50019056 D0V5WL GTPL1614 Met5-Enkephalin Methionine enkephalin TYR-GLY-GLY-PHE-MET [Met]-enkephalin 9JEZ9OD3AS CCRIS 4225 DTXSID80332078 KS-00000GEH [ Show all ]
Inchi Key	YFGBQHOOROIVKG-FKBYEOEOSA-N
Inchi ID	InChI=1S/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1
PubChem CID	443363
ChEMBL	CHEMBL13786
IUPHAR	1614
BindingDB	50019056
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1.0 nM	, Bioorg. Med. Chem. Lett., (1992) 2:3:219	BindingDB,ChEMBL
Ki	7.3 nM	PMID2845081	BindingDB,ChEMBL

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