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GPCR

Name	Cannabinoid receptor 2
Species	Homo sapiens (Human)
Gene	CNR2
Synonym	Peripheral cannabinoid receptor rCB2 hCB2 cannabinoid receptor 2 (macrophage) cannabinoid receptor 2 (spleen) CB-2 CB2 CB2 receptor CB2-R CX5 [ Show all ]
Disease	Immune disorder Inflammatory bowel disease Inflammatory disease Neuropathic pain Osteoporosis Pain Atopic dermatitis Rheumatoid arthritis [ Show all ]
Length	360
Amino acid sequence	MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProt	P34972
Protein Data Bank	5zty
GPCR-HGmod model	P34972
3D structure model	This structure is from PDB ID 5zty.
BioLiP	BL0438927
Therapeutic Target Database	T37693
ChEMBL	CHEMBL253
IUPHAR	57
DrugBank	BE0000095

Ligand

Name	N-arachidonylglycine
Molecular formula	C22H35NO3
IUPAC name	2-[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]amino]acetic acid
Molecular weight	361.526
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.6
Synonyms	Lopac0_000074 N-Arachidonyl Glycine NCGC00015042-03 NCGC00015042-11 NSC-746569 179113-91-8 YLEARPUNMCCKMP-DOFZRALJSA-N AKOS024456602 C22H35NO3 DSSTox_GSID_45124 HMS1791I06 N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)glycine N-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]glycine NCGC00015042-06 NCGC00093582-05 SR-01000076205 B6742 CHEBI:58961 EU-0100074 HMS3649B11 LMFA08020003 N-arachidonoylglycine NCGC00015042-01 NCGC00015042-09 NCGC00093582-08 ((5Z,8Z)-Icosa-5,8,11,14-tetraenoylamino)-acetic acid Tox21_110070 AC1NR26D BRD-K51557114-001-02-1 D01ZHW GTPL3635 LP00074 N-arachidonyl-L-glycine NCGC00015042-04 NCGC00093582-01 NSC746569 1909AH ZINC4467867 arachidonoyl glycine CAS-179113-91-8 DSSTox_RID_80688 HMS1989I06 N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycine N-[1-Oxo-5Z,8Z,11Z,14Z-eicosatetraenyl]glycine NCGC00015042-07 NCGC00093582-06 SR-01000076205-1 BDBM50056486 FA-029 IDI1_033914 Lopac-A-1977 N-arachidonoylglycine, methylene chloride solution NCGC00015042-02 NCGC00015042-10 NCGC00093582-09 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoylamino)-acetic acid Tox21_110070_1 ACM179113918 BSPBio_001444 DSSTox_CID_25124 HMS1361I06 MolPort-003-940-077 NCGC00015042-05 NCGC00093582-04 SCHEMBL158050 2-[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]amino]acetic acid arachidonoylglycine CCG-204169 DTXSID5045124 HMS3402I06 J-011429 N-arachidonoyl glycine NAGly NCGC00015042-08 NCGC00093582-07 SR-01000076205-5 A 1977 BML2-C05 CHEMBL161343 Glycine,N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]- [ Show all ]
Inchi Key	YLEARPUNMCCKMP-DOFZRALJSA-N
Inchi ID	InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/b7-6-,10-9-,13-12-,16-15-
PubChem CID	5283389
ChEMBL	CHEMBL161343
IUPHAR	3635
BindingDB	50056486
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	36.0 %	MedChemComm, (2014) 5:5:632	ChEMBL
Ki	<10000.0 nM	MedChemComm, (2014) 5:5:632	ChEMBL

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