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GPCR

Name	Cannabinoid receptor 1
Species	Rattus norvegicus (Rat)
Gene	Cnr1
Synonym	SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor CB1 CB-R Cann7 Cann6 Brain-type cannabinoid receptor THC receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	473
Amino acid sequence	MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
UniProt	P20272
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3571
IUPHAR	56
DrugBank	N/A

Ligand

Name	N-arachidonylglycine
Molecular formula	C22H35NO3
IUPAC name	2-[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]amino]acetic acid
Molecular weight	361.526
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.6
Synonyms	BSPBio_001444 DSSTox_CID_25124 HMS1361I06 Lopac-A-1977 N-arachidonoylglycine, methylene chloride solution NCGC00015042-02 NCGC00015042-10 NCGC00093582-09 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoylamino)-acetic acid Tox21_110070_1 ACM179113918 CCG-204169 DTXSID5045124 HMS3402I06 MolPort-003-940-077 NCGC00015042-05 NCGC00093582-04 SCHEMBL158050 2-[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]amino]acetic acid arachidonoylglycine BML2-C05 CHEMBL161343 Glycine,N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]- J-011429 N-arachidonoyl glycine NAGly NCGC00015042-08 NCGC00093582-07 SR-01000076205-5 A 1977 C22H35NO3 DSSTox_GSID_45124 HMS1791I06 Lopac0_000074 N-Arachidonyl Glycine NCGC00015042-03 NCGC00015042-11 NSC-746569 179113-91-8 YLEARPUNMCCKMP-DOFZRALJSA-N AKOS024456602 CHEBI:58961 EU-0100074 HMS3649B11 N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)glycine N-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]glycine NCGC00015042-06 NCGC00093582-05 SR-01000076205 B6742 BRD-K51557114-001-02-1 D01ZHW GTPL3635 LMFA08020003 N-arachidonoylglycine NCGC00015042-01 NCGC00015042-09 NCGC00093582-08 ((5Z,8Z)-Icosa-5,8,11,14-tetraenoylamino)-acetic acid Tox21_110070 AC1NR26D CAS-179113-91-8 DSSTox_RID_80688 HMS1989I06 LP00074 N-arachidonyl-L-glycine NCGC00015042-04 NCGC00093582-01 NSC746569 1909AH ZINC4467867 arachidonoyl glycine BDBM50056486 FA-029 IDI1_033914 N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycine N-[1-Oxo-5Z,8Z,11Z,14Z-eicosatetraenyl]glycine NCGC00015042-07 NCGC00093582-06 SR-01000076205-1 [ Show all ]
Inchi Key	YLEARPUNMCCKMP-DOFZRALJSA-N
Inchi ID	InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21(24)23-20-22(25)26/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-20H2,1H3,(H,23,24)(H,25,26)/b7-6-,10-9-,13-12-,16-15-
PubChem CID	5283389
ChEMBL	CHEMBL161343
IUPHAR	3635
BindingDB	50056486
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID9057852	BindingDB,ChEMBL

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